Topical formulations for delivery of interleukin-11

Abstract

Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis, indeterminate colitis, and infectious colitis), mucositis (e.g., oral mucositis, gastrointestinal mucositis, nasal mucositis, and proctitis), necrotizing enterocolitis, inflammatory skin disorders (e.g., psoriasis, atopic dermatitis, and contact hypersensitivity), aphthous ulcers, pharyngitis, esophagitis, peptic ulcers, gingivitis, periodontitis, and ocular diseases (e.g., conjunctivitis, retinitis, and uveitis).

We claim:  
     
         1 . A method of treating Inflammatory Bowel Disease comprising administering to a patient a topical formulation of a pharmaceutical composition composed of a pharmaceutically effective amount of IL-11 and a carrier for delivery of IL-11 to the gastrointestinal tract.  
     
     
         2 . The method of  claim 1 , wherein said carrier is an immediate release carrier.  
     
     
         3 . The method of  claim 2 , wherein said immediate release carrier comprises a collection of multi-particulate particles.  
     
     
         4 . The method of  claim 3 , wherein said multi-particulate particles comprise sugar beads.  
     
     
         5 . The method of  claim 1 , wherein said carrier has an enteric coating.  
     
     
         6 . A method of treating Inflammatory Bowel Disease comprising administering to a patient a topical formulation of a pharmaceutical composition composed of multi-particulate, enteric-coated particles containing a pharmaceutically effective amount of IL-11.  
     
     
         7 . A composition for treating Inflammatory Bowel Disease comprising a topical formulation composed of a pharmaceutically effective amount of IL-11 and a suitable solid carrier.  
     
     
         8 . The composition of  claim 7 , wherein said carrier is an immediate release carrier.  
     
     
         9 . The composition of  claim 8 , wherein said immediate release carrier comprises a collection of multi-particulate particles.  
     
     
         10 . The composition of  claim 9 , wherein said multi-particulate particles comprise sugar beads.  
     
     
         11 . The composition of  claim 7 , wherein said formulation additionally comprises an enteric coating.  
     
     
         12 . A composition for treating Inflammatory Bowel Disease comprising a topical formulation composed of multi-particulate, enteric-coated particles containing a pharmaceutically effective amount of IL-11.