US2003139458A1PendingUtilityA1

Treatment of neurodegenerative and cardiovascular disorders

37
Priority: Dec 10, 2001Filed: Dec 10, 2002Published: Jul 24, 2003
Est. expiryDec 10, 2021(expired)· nominal 20-yr term from priority
Inventors:Yansheng DuMartin FarlowRuyu Du
A61P 9/00A61K 31/275A61P 25/00A61K 31/40A61P 25/28A61K 31/13A61K 31/16A61P 25/16A61K 31/215A61K 31/44
37
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Claims

Abstract

A method of treating a neurodegenerative or cardiovascular disorder with a compound of the following formula: in which X, Y, A 1 , A 2 , R 1 , and R 2 are defined herein.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A method of treating a neurodegencrative or cardiovascular disorder, comprising administering to the subject in need thereof an effective amount of a compound of the following formula:  
       
         
           
           
               
               
           
         
       
       in which 
 each of R 1  and R 2 , independently, is C 1-8  alkylene, C 2-8  alkenylene, or deleted;  
 each of A 1  and A 2  , independently, is aryl or heteroaryl, optionally substituted with halogen, —CN, —NO 2 , —OH, —SH, —OR 3 , —SR 3 , —R 3 , —R 3 —OR 4 , —C(O)R 3 , —S(O)R 3 , —S(O) 2 R 3 , —NR 4 R 5 , —C(O)OR 3 , —C(O)NR 4 R 5 , —O(O)CR 4  or —NR 4 (O)CR 5 ; and  
 each of X and Y, independently, is O, S, or NR 6 ,  
 wherein each R 3  is C 1-4  alkyl, and each of R 4 , R 5 , and R 6 , independently, is H or C 1-4  alkyl.  
 
     
     
         2 . The method of  claim 1 , wherein each of X and Y, independently, is O.  
     
     
         3 . The method of  claim 2 , wherein R 1  is a C 2-8  alkenylene and R 2  is a C 1-8  alkylene.  
     
     
         4 . The method of  claim 3 , wherein R 1  is a C 2-3  alkenylene and R 2  is a C 1-3  alkylene.  
     
     
         5 . The method of  claim 4 , wherein each of A 1  and A 2 , independently, is aryl, optionally substituted with halogen, —CN, —OH, —SH, —OR 3 , —SR 3 , —R 3 , —R 3 —OR 4 , or —NR 4 R 5 .  
     
     
         6 . The method of  claim 4 , wherein R 1  is —CH═CH— and R 2  is —CH 2 —CH 2 —.  
     
     
         7 . The method of  claim 6 , wherein each of A 1  and A 2 , independently, is aryl, optionally substituted with halogen, —CN, —OH, —SH, —OR 3 , —SR 3 , —R 3 , —R 3 —R 4 , or —NR 4 R 5 .  
     
     
         8 . The method of  claim 7 , wherein each of each of A 1  and A 2 , independently, is phenyl optionally substituted with —OH or —SH.  
     
     
         9 . The method of  claim 2 , wherein each of A 1  and A 2 , independently, is aryl, optionally substituted with halogen, —CN, —OH, —SH, —OR 3 , —SR 3 , —R 3 , —R 3 —OR 4 , or —NR 4 R 5 .  
     
     
         10 . The method of  claim 9 , wherein each of A 1  and A 2 , independently, is phenyl, optionally substituted with —OH or —SH.  
     
     
         11 . The method of  claim 1 , wherein R 1  is a C 2-8  alkenylene, and R 2  is a C 1-8  alkylene.  
     
     
         12 . The method of  claim 11 , wherein R 1  is a C 2-3  alkenylene, and R 2  is a C 1-3  alkylene  
     
     
         13 . The method of  claim 12 , wherein R 1  is —CH═CH—, and R 2  is —CH 2 —CH 2 —.  
     
     
         14 . The method of  claim 12 , wherein each of A 1  and A 2 , independently, is aryl, optionally substituted with halogen, —CN, —OH, —SH, —OR 3 , —SR 3 , —R 3 , —R 3 —OR 4 , or —NR 4 R 5 .  
     
     
         15 . The method of  claim 14 , wherein A 1  is 3,4-dihyoxyphenyl and A 2  is phenyl.  
     
     
         16 . The method of  claim 15 , wherein R 1  is —CH═CH—; R 2  is —CH 2 —CH 2 —; and each of X and Y, independently, is O.  
     
     
         17 . The method of  claim 1 , wherein each of A 1  and A 2 , independently, is aryl, optionally substituted with halogen, —CN, —OH, —SH, —OR 3 , —SR 3 , —R 3 , —R 3 —OR 4 , or —NR 4 R 5 .  
     
     
         18 . The method of  claim 17 , wherein each of A 1  and A 2 , independently, is phenyl, optionally substituted with —OH or —SH.  
     
     
         19 . A particle of manufacture comprising: 
 i) a container;    ii) an effective amount of a compound, disposed in the container, and having the following formula:                          in which    each of R 1  and R 2 , independently, is C 1-8  alkylene, C 2-8  alkenylene, or deleted;    each of A 1  and A 2 , independently, is aryl or heteroaryl, optionally substituted with halogen, —CN, —NO 2 , —OH, —SH, —OR 3 , —SR 3 , —R 3 , —R 3 —OR 4 , —C(O)R 3 , —S(O)R 3 , —S(O) 2 R 3 , —NR 4 R 5 , —C(O)OR 3 , —C(O)NR 4 R 5 , —O(O)CR 4 , or —NR 4 (O)CR 5 ; and    each of X and Y, independently, is O, S, or NR 6 ,    wherein each R 3  is C -4  alkyl, and each of R 4 , R 5 , and R 6 , independently, is H or C 1-4  alkyl; and    iii) a label, disposed on the container and having instructions for treating a neurodegenerative or cardiovascular disorder.    
     
     
         20 . The particle of manufacture of  claim 19 , wherein each of X and Y, independently, is O; R 1  is a C 2-3  alkenylene; R 2  is a C 1-3  alkylene; and each of A 1  and A 2 , independently, is aryl, optionally substituted with halogen, —CN, —OH, —SH, —OR 3 , —SR 3 , —R 3 , —R 3 —OR 4 , or —NR 4 R 5 .  
     
     
         21 . The particle of manufacture of  claim 20 , wherein R 1  is —CH═CH—; R 2  is —CH 2 —CH 2 —; A 1  is 3,4-dihydroxy phenyl; and A 2  is phenyl.

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