US2003138383A1PendingUtilityA1
Irrigation solution and methods for use
Priority: Jan 23, 2002Filed: Jan 23, 2002Published: Jul 24, 2003
Est. expiryJan 23, 2022(expired)· nominal 20-yr term from priority
A61K 6/40A61K 6/50
54
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Claims
Abstract
Methods and solutions are provided for removal of the smear layer on prepared tooth and bone surfaces, especially in endodontic environments.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A method for removing smear layer from a prepared tooth surface comprising irrigating the surface with a sterile solution comprising:
disinfectant; detergent; and organic acid.
2 . The method of claim 1 wherein the disinfectant is an antibiotic.
3 . The method of claim 2 wherein the antibiotic is substantially stable in acidic solution.
4 . The method of claim 3 wherein the antibiotic is a tetracycline.
5 . The method of claim 4 wherein the antibiotic is doxycycline.
6 . The method of claim 1 wherein the detergent is a Food and Drug Administration-approved additive.
7 . The method of claim 6 wherein the detergent is a sorbitan ester.
8 . The method of claim 6 wherein the detergent is a polysorbate.
9 . The method of claim 8 wherein the detergent is polyoxyethylene sorbitan monooleate.
10 . The method of claim 1 wherein the organic acid has a pKa between 1.5 and 5.
11 . The method of claim 1 wherein the organic acid has a pKa between 2 and 5.
12 . The method of claim 1 wherein the organic acid has a pKa between 2.75 and 3.75.
13 . The method of claim 12 wherein the organic acid is citric acid.
14 . The method of claim 1 wherein the surface is an endodontic situs.
15 . The method of claim 1 wherein the surface is an excavated root canal.
16 . The method of claim 1 wherein the surface is a surface prepared for a periodontic procedure.
17 . The method of claim 1 wherein the surface is a prepared site for tooth restoration.
18 . The method of claim 1 wherein the surface has been prepared for reconstruction of a tooth.
19 . The method of claim 1 wherein the tooth surface is irrigated for between 1 minute and 1 hour.
20 . The method of claim 1 wherein the tooth surface is irrigated for from about 1 to 30 minutes.
21 . The method of claim 1 wherein the tooth surface is irrigated for from about 1 to 10 minutes.
22 . The method of claim 1 wherein the disinfectant is present in an amount of from about 1 to 5 percent by weight of the solution.
23 . The method of claim 1 wherein the disinfectant is present in an amount of from about 2 to 4 percent by weight of the solution.
24 . The method of claim 1 wherein the disinfectant is present in an amount of about 3 percent by weight of the solution.
25 . The method of claim 1 wherein the detergent is present in an amount of from about 0.1 to 1.5 percent by weight of the solution.
26 . The method of claim 1 wherein the detergent is present in an amount of from about 0.25 to 1 percent by weight of the solution.
27 . The method of claim 1 wherein the detergent is present in an amount of about 0.5 percent by weight of the solution.
28 . The method of claim 1 wherein the acid is present in an amount of from about 0.5 to 10 percent by weight of the solution.
29 . The method of claim 1 wherein the acid is present in an amount of from about 3 to 6 percent by weight of the solution.
30 . The method of claim 1 wherein the acid is present in an amount of from about 4 to 5 percent by weight of the solution.
31 . The method of claim 1 , wherein the composition of the solution is about 3% disinfectant, 0.5% detergent, and 4.25% acid by weight.
32 . The method of claim 1 wherein the solution comprises doxycycline, polysorbate 80, and citric acid.
33 . The method of claim 1 , wherein the composition of the solution is about 3% doxycycline, about 0.5% polysorbate 80, and about 4.25% citric acid by weight.
34 . A sterile solution for removing the smear layer on a prepared surface comprising:
disinfectant; detergent; and organic acid.
35 . The solution of claim 34 wherein the disinfectant is an antibiotic.
36 . The solution of claim 35 wherein the antibiotic is substantially stable in acidic solution.
37 . The solution of claim 36 wherein the antibiotic is a tetracycline.
38 . The solution of claim 37 wherein the antibiotic is doxycyline.
39 . The solution of claim 34 wherein the detergent is a Food and Drug Administration-approved additive.
40 . The solution of claim 39 wherein the detergent is a sorbitan ester compound.
41 . The solution of claim 40 wherein the detergent is a polysorbate compound.
42 . The solution of claim 41 wherein the polysorbate compound is polysorbate 80.
43 . The solution of claim 34 wherein the organic acid has a pKa between 1.5 and 5.
44 . The solution of claim 43 wherein the organic acid has a pKa between 2 and 5.
45 . The solution of claim 44 wherein the organic acid has a pKa between 2.75 and 3.75.
46 . The solution of claim 45 wherein the organic acid is citric acid.
47 . The solution of claim 34 wherein the disinfectant is present in an amount of from about 1 to 5 percent by weight of the solution.
48 . The solution of claim 34 wherein the disinfectant is present in an amount of from about 2 to 4 percent by weight of the solution.
49 . The solution of claim 34 wherein the disinfectant is present in an amount of about 3 percent by weight of the solution.
50 . The solution of claim 34 wherein the detergent is present in an amount of from about 0.1 to 1.5 percent by weight of the solution.
51 . The solution of claim 34 wherein the detergent is present in an amount of from about 0.25 to 1 percent by weight of the solution.
52 . The solution of claim 34 wherein the detergent is present in an amount of about 0.5 percent by weight of the solution.
53 . The solution of claim 34 wherein the acid is present in an amount of from about 0.5 to 10 percent by weight of the solution.
54 . The solution of claim 34 wherein the acid is present in an amount of from about 3 to 6 percent by weight of the solution.
55 . The solution of claim 34 wherein the acid is present in an amount of from about 4 to 5 percent by weight of the solution.
56 . The solution of claim 34 wherein the composition of the solution is about 3% disinfectant, 0.5% detergent, and 4.25% acid by weight.
57 . The solution of claim 34 wherein the solution comprises doxycycline, polysorbate 80, and citric acid.
58 . The solution of claim 57 wherein the composition of the solution is about 3% doxycycline, about 0.5% polysorbate 80, and about 4.25% citric acid by weight.
59 . A method for removing smear layer from a prepared bone surface comprising irrigating the surface with a sterile solution comprising:
disinfectant; detergent; and organic acid.Join the waitlist — get patent alerts
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