US2003135037A1PendingUtilityA1

Expression and secretion of heterologous polypeptides from caulobacter

Assignee: UNIV BRITISH COLUMBIA A CANADAPriority: Jun 9, 1992Filed: Aug 19, 2002Published: Jul 17, 2003

Est. expiryJun 9, 2012(expired)· nominal 20-yr term from priority

Inventors:John Smit Wade H. Bingle John F. Nomellini

A61K 39/00C07K 2319/00C07K 14/005C07K 14/21C12N 15/74C12N 2760/20022

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Claims

Abstract

DNA constructs are provided which code for at least the extreme C-terminal amino acids of the rsaA protein of Caulobacter crescentus fused with heterologous polypeptides. Baterial cells containing, or which express the DNA constructs and secrete the resulting protein are also provided. Chimeric proteins including the C-terminal amino acids of the rsaA protein are provided, including chimeric proteins comprising antigenic epitopes of the Infectious Hematopoietic Necrosis Virus.

Claims

exact text as granted — not AI-modified

We claim:  
     
         1 . A DNA construct comprising in sequence, one or more restriction sites for facilitating insertion of DNA to the construct and, DNA encoding at least the C-terminal region of the rsaA protein of  C. crescentus , wherein the C-terminal region comprises at least amino acids 944-1026 of the rsaA protein.

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