Glycoprotein llb/llla antagonists

Abstract

This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.

What is claimed:  
     
         1 . A bicyclic compound having a nucleus formed from two fused six membered rings, A and B, represented by the formula (I), or a pharmaceutically acceptable salt, solvate or prodrug derivative thereof:  
       
         
           
           
               
               
           
         
       
       wherein; 
 the bicyclic nucleus of rings A and B is selected from the group consisting of formulae (17) through (21) below:  
                     
 R 3  is an acidic group containing one or more acid radicals;  
 n is a number from 0 to 6;  
 R 0  is the same or different and is independently selected from hydrogen, alkyl, halosubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, hydroxy, alkoxy, aralkoxy, amino, substituted amino, carbamoyl, carboxy, acyl, cyano, halo, nitro, sulfo, ═O, or ═S;  
 m is a number from 0 to 6;  
 R 10  is the same or different and is independently selected from hydrogen, alkyl, halosubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, hydroxy, alkoxy, aralkoxy, carboxy, acyl, cyano, halo, nitro, sulfo, ═O, or ═S; with the proviso that only one R 10  may be ═O or ═S;  
 linking group -(L)- is a bond or a divalent substituted or unsubstituted chain of from 1 to 10 atoms selected from the group consisting of carbon, nitrogen, sulfur, and oxygen; and;  
 Q is a basic group containing one or more basic radicals.