GDU, a novel signalling protein

Abstract

The present invention provides the nucleotide and amino acid sequence of a previously unidentified erbB receptor target. The nucleotide and amino acid sequence is set out in the figure.

1 . A polynucleotide encoding GDU, the polynucleotide having a sequence which encodes a polypeptide having an amino acid sequence as shown in FIG. 2 or a sequence which hybridises thereto.  
     
     
         2 . A polynucleotide as claimed in  claim 1  in which the polynucleotide has a sequence as shown in FIG. 2.  
     
     
         3 . A GDU polypeptide, the polypeptide having an amino acid sequence as shown in FIG. 2.  
     
     
         4 . An antibody which binds to the polypeptide as claimed in  claim 3 .  
     
     
         5 . An antibody as claimed in  claim 4  in which the antibody is a monoclonal antibody.  
     
     
         6 . An oligonucleotide probe of at least 12 nucleotides, the oligonucleotide probe having a sequence such that the probe selectively hybridises to the polynucleotide as claimed in  claim 1  under stringent conditions.  
     
     
         7 . An oligonucleotide probe as claimed in  claim 6  in which the oligonucleotide probe is labelled.  
     
     
         8 . An-oligonucleotide probe as claimed in  claim 6  or  claim 7  in which the oligonucleotide is of at least 18 nucleotides.  
     
     
         9 . A method of detecting the presence of GDU in a sample, the method comprising reacting the sample with an antibody as claimed in  claim 4  or  claim 5  or an oligonucleotide probe as claimed in any one of  claims 6  to  8  and detecting the binding of the antibody or the probe.