Treatment of functional gastrointestinal disorders

Abstract

Tramadol or a pharmaceutically acceptable salt thereof is used in the manufacture of a pharmaceutical preparation for the treatment of functional gastrointestinal disorders such as irritable bowel syndrome.

1 . The use of tramadol or a pharmaceutically acceptable salt thereof in the manufacture of a pharmaceutical preparation for the treatment of functional gastrointestinal disorders.  
     
     
         2 . The use according to  claim 1  wherein the functional gastrointestinal disorder is irritable bowel syndrome.  
     
     
         3 . The use according to  claim 1  or  2  wherein the tramadol or pharmaceutically acceptable salt thereof is (1RS,2RS)-Tramadol optionally with a minor amount of (1RS,2SR) Tramadol, or pharmaceutically acceptable salts thereof.  
     
     
         4 . The use according to  claim 1  or  2  wherein the tramadol or pharmaceutically acceptable salt thereof is in the form of one of its enantiomers.  
     
     
         5 . The use according to any of the preceding claims, wherein the pharmaceutically acceptable salt is tramadol hydrochloride.  
     
     
         6 . The use of according to any one of the preceding claims wherein the medicament is in unit dosage form such as a tablet or capsule.  
     
     
         7 . The use according to  claim 6  wherein the unit dosage form is a normal release dosage form.  
     
     
         8 . The use according to  claim 6  wherein the unit dosage form is a controlled release dosage form.  
     
     
         9 . The use according to any one of the preceding claims, wherein the tramadol is to be dosed in an amount of 10 mg to 400 mg (calculated as tramadol hydrochloride) per day.  
     
     
         10 . The use according to  claim 9 , wherein the tramadol is to be dosed in an amount of 50 mg to 200 mg, preferably 25 mg to 100 mg (calculated as tramadol hydrochloride) per day.  
     
     
         11 . The use according to  claim 10 , wherein the tramadol is to be dosed in an amount of 50 mg to 100 mg (calculated as tramadol hydrochloride) per day.  
     
     
         12 . The use according to any preceding claim, with administration of the tramadol in combination with another therapeutic agent.  
     
     
         13 . The use according to  claim 12 , wherein the tramadol and another therapeutic agent are in a combination product.  
     
     
         14 . A method of treating a functional gastro-intestinal disorder, especially irritable bowel syndrome, which comprises administering to a patient suffering from said disorder a pharmaceutical preparation as defined in any one of the preceding claims.  
     
     
         15 . A pharmaceutical preparation containing tramadol for use in the treatment of a functional gastro-intestinal disorder, especially irritable bowel syndrome, in a patient suffering therefrom.  
     
     
         16 . A pharmaceutical preparation according to  claim 15 , further containing another therapeutic agent.