Medicated chewing-gum

Abstract

The present invention is directed to chewing-gum preparations which are particularly useful for treating gastroesophageal reflux disease. Typically, the chewing-gum preparation comprises a chewing-gum base and more than one ingredient selected from the group consisting of an acid neutralizing agent, an anti-gas agent, and an acid production inhibitor, and desirably all three ingredients. The invention is also directed to a method for treating gastroesophageal reflux disease comprising the step of masticating a chewing-gum preparation including a gum base and more than one ingredient selected from the group consisting of an acid neutralizing agent, an anti-gas agent, and an acid production inhibitor, and desirably all three ingredients.

What is claimed is:  
     
         1 . A masticatory for treating gastroesophageal reflux disease comprising: a chewing-gum base; and at least one ingredient selected from the group consisting of an acid neutralizing agent, and an acid production inhibitor.  
     
     
         2 . The masticatory of  claim 1  wherein the acid neutralizing agent is selected from the group consisting of calcium carbonate, magnesium oxide, magnesium hydroxide, magnesium trisilicate, magnesium carbonate, aluminum hydroxide and mixtures thereof.  
     
     
         3 . The masticatory of  claim 1  wherein the acid production inhibitor is selected from the group consisting of H-2 receptor antagonists, proton pump inhibitors, their hydrochloride salts, and mixtures thereof.  
     
     
         4 . The masticatory of  claim 1  further comprising a flavoring agent.  
     
     
         5 . The masticatory of  claim 4  wherein the flavoring agent is selected from the group consisting of menthol, organic acids, oil of cinnamon, oil of wintergreen, oil of peppermint, oil of spearmint, oil of sassafras, and oil of clove.  
     
     
         6 . The masticatory of  claim 5  further including a sweetening agent.  
     
     
         7 . The masticatory of  claim 6  wherein the sweetening agent is selected from the group consisting of sucrose, glucose, dextrose, levulose, saccharin salts, thaumatin, aspartame, D-tryptophan, dihydrochalcones, acesulfame salts and cyclamate salts.  
     
     
         8 . A chewing-gum composition for the treatment of gastroesophageal reflux disease comprising: a chewing-gum integral with a chewable tablet, the chewable tablet including more than one ingredient selected from the group consisting of an acid neutralizing agent, and an acid production inhibitor.  
     
     
         9 . The chewing-gum composition of  claim 8  wherein the chewing-gum is contained in the chewable tablet.  
     
     
         10 . The chewing-gum composition of  claim 8  wherein the chewable tablet is contained in the chewing-gum.  
     
     
         11 . The chewing-gum composition of  claim 8  wherein the acid neutralizing agent is selected from the group consisting of calcium carbonate, magnesium oxide, magnesium hydroxide, magnesium trisilicate, magnesium carbonate, aluminum hydroxide and mixtures thereof.  
     
     
         12 . The chewing-gum composition of  claim 8  wherein the acid production inhibitor is selected from the group consisting of H-2 receptor antagonists, proton pump inhibitors, their hydrochloride salts, and mixtures thereof.  
     
     
         13 . The chewing-gum composition of  claim 8  further comprising a flavoring agent selected from the group consisting of menthol, organic acids, oil of cinnamon, oil of wintergreen, oil of peppermint, oil of spearmint, oil of sassafras, and oil of clove.  
     
     
         14 . The chewing-gum composition of  claim 8  further including a sweetening agent selected from the group consisting of sucrose, glucose, dextrose, levulose, saccharin salts, thaumatin, aspartame, D-tryptophan, dihydrochalcones, acesulfame salts and cyclamate salts.  
     
     
         15 . A method for treating gastroesophageal reflux disease comprising the step of masticating a chewing-gum preparation including a gum base and more than one ingredient selected from the group consisting an acid neutralizing agent, and an acid production inhibitor.  
     
     
         16 . The method of  claim 15  wherein the acid neutralizing agent; and the acid production inhibitor are formed into a chewable tablet which is integral with the chewing-gum base.