US2003109048A1PendingUtilityA1
Process for the production of a flavor or a fragrance formulation or for the determination of the use of a flavor or fragrance ingredient in a flavor or fragrance formulation or use thereof in or on a perfume composition, a perfumed article, a cologne, a foodstuff, a beverage, an oral care product and/or chewing gum as well as an electronic data processing software program therefor
Priority: May 19, 2000Filed: Nov 22, 2002Published: Jun 12, 2003
Est. expiryMay 19, 2020(expired)· nominal 20-yr term from priority
Y10T436/12A61K 2800/412A61Q 11/00B01J 13/08A23L 27/00C11B 9/00A61K 8/11
39
PatentIndex Score
0
Cited by
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References
0
Claims
Abstract
A process and electronic data processing software program for the creation of a flavor or fragrance formulation or the use of a fragrance or flavor ingredient in a fragrance or flavor formulation used in a perfume composition, perfumed article, cologne, foodstuff, beverage, and oral care products is disclosed. The process employs a laser light beam transmitter fitted with a light scattering means attached to a titration means. The titration means consists of two burettes: (a) a “sample” burette and (b) a “titrant” burette. The “sample” burette holds one or more fragrance or flavor ingredients or a fragrance or flavor formulation. The “titrant” burette holds a solvent such as water.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A process for the creation of a fragrance or flavor formulation or ascertainment of the use of a fragrance or flavor ingredient in a flavor or fragrance formulation or use thereof on or in a foodstuff, beverage, chewing gum, oral care composition, perfume composition, cologne, perfumed article or a perfumed polymer having predictable solvent solubility comprising the steps of:
(i) providing a laser light beam transmitter fitted with a laser light scattering means; (ii) providing a titration means upstream from and cooperating with said laser light scattering means consisting of two injection means, a first “titrant” injection means containing a solvent and a second “sample” injection means containing a flavor or fragrance formulation or a flavor or fragrance ingredient, each of said injection means being connected to fluid transmission means for transmitting and mixing said titrant with said sample to create a dynamic titrant/sample mixture in the liquid phase; (iii) continuously transporting said dynamic titrant/sample mixture through said laser light scattering means while substantially simultaneously (a) titrating said dynamic titrant/sample mixture to a solvent solubility endpoint and (b) monitoring said dynamic titrant/sample mixture in order to ascertain the dimensions of microparticles or globules or micelles or microcapsules formed or enlarged while said dynamic titrant/sample mixture is being transported within said laser light scattering means.
2 . The process of claim 1 wherein the titrant is water and the sample is a mixture of surfactant and fragrance or flavor ingredient or formulation; and the endpoint is represented by the formation and enlargement of micelles.
3 . The process of claim 1 wherein the dynamic titrant/sample mixture is initially a single phase mixture and the arrival of the endpoint is represented by the formation of a colloid containing microdroplets of fragrance or flavor formulation or fragrance or flavor ingredient.
4 . The process of claim 1 wherein the titrant is a mixture of water and gelatin and the sample is a flavor or fragrance ingredient; and the endpoint is represented by formation and enlargement of a coacervate wherein enlarged gelatin microcapsules containing fragrance or flavor ingredient are formed.
5 . The process of claim 1 comprising the additional step of using the solubility data generated from endpoint microparticle size or microglobule size or micelle size or microcapsule size data to ascertain solvent solubility of flavor or fragrance ingredients or formulations, and then crafting formulations using said data.
6 . The process of claim 5 comprising the additional step of adding the resulting formulation to a perfumed article base which is a liquid aqueous detergent base.
7 . The process of claim 1 comprising the additional step of using the solubility data generated from endpoint microparticle size or microglobule size or microcapsule size or micelle size data to ascertain solvent solubility of a series of flavor ingredients or flavor formulations and then crafting a flavor formulation therefrom.
8 . The process of claim 7 comprising the additional step of adding the resulting formulation to an aqueous beverage.
9 . The process of claim 2 comprising the additional step of using the solubility data generated from endpoint microparticle size or microglobule size or micelle size or microcapsule size data to ascertain solvent solubility of flavor or fragrance ingredients or formulations, and then crafting formulations using said data.
10 . The process of claim 9 comprising the additional step of adding the resulting formulation to a perfumed article base which is a liquid aqueous detergent base.
11 . The process of claim 3 comprising the additional step of using the solubility data generated from endpoint microparticle size or microglobule size or micelle size or microcapsule size data to ascertain solvent solubility of flavor or fragrance ingredients or formulations, and then crafting formulations using said data.
12 . The process of claim 11 comprising the additional step of adding the resulting formulation to a perfumed article base which is a liquid aqueous detergent base.
13 . The process of claim 4 comprising the additional step of using the solubility data generated from endpoint microparticle size or microglobule size or micelle size or microcapsule size data to ascertain solvent solubility of flavor or fragrance ingredients or formulations, and then crafting formulations using said data.
14 . The process of claim 13 comprising the additional step of adding the resulting formulation to a perfumed article base which is a liquid aqueous detergent base.
15 . Means for a creation of electronic data processing software designed to yield information concerning microparticle, microglobule, micelle or microcapsule dimensions which will yield solvent solubility data for fragrance ingredients and fragrance compositions comprising:
(i) means for ascertainment of light scattering material which is to be subjected to a laser light beam transmitter fitted with a light scattering means and having attached thereto titration means and tracing means holding a solvent and sample means holding a fragrance ingredient or fragrance formulation with the occurrence of the titration endpoint taking place at the location of the light scattering means; and associated therewith means for input of data to memory; (ii) means for establishing constraints for:
(a) fragrance ingredient or formulation aroma profile;
(b) fragrance ingredient or formulation profile on treated product; and
(c) total fragrance/solvent solubility and means for input to memory;
(iii) means for loading a sample syringe with fragrance ingredient or fragrance formulation and means for loading titrating material into titrant syringe; (iv) means for instructing the setting of the system to reject fragrance ingredients having given solvent solubilities and to reject a fragrance formulation having a given solvent solubility with the rejection instruction being: S i ≦S A and with the acceptance instruction being: S i >S A wherein S i is the solubility in gram moles per liter of a fragrance ingredient and S A is the acceptable solubility of the fragrance ingredient; and, in the case of a fragrance formulation, with the rejection constraint: [ΣS i ]≦S B and the acceptance constraint: [ΣS i ]>S B ; with associated data input to memory; (v) means for instructing the engagement of sample/titrant syringes simultaneously with engagement of laser light scattering apparatus; (vi) means for instructing acceptance if the endpoint exists at f≧0.2 and means for instructing rejection if the endpoint exists at f<0.2, with associated inputs to memory; (vii) means for instructing acceptance of previously accepted material under the constraint: S i >S A , with associated input to memory; and means for instructing rejection of the sample under the constraint: S i ≦S A , with associated input to memory; (viii) means for instructing the repeating of prior steps (iii), (iv), (v), (vi) and (vii) for different loading rates and for the repetition of creation of different fragrance ingredients and fragrance formulations; and (ix) means for instructing the carrying out of actual testing for total fragrance evaluation with respect to properties of aroma and solvent solubility with associated instructions for rejection if not odor acceptable; rejection under the constraint: [ΣS i ]≦S B ; or acceptance if odor acceptable and under the constraint: [ΣS i ]>S B , with associated instructions for reformulation if not odor acceptable whereby steps (iii), (iv), (v), (vi), (vii), (viii) and (ix) are repeated; and wherein f represents the fraction of substance originally in the titrant or sample syringe which is consumed during the titration.
16 . Means for a creation of electronic data processing software designed to yield information concerning microparticle, microglobule, micelle or microcapsule dimensions which will yield solvent solubility data for flavor ingredients and flavor compositions comprising:
(i) means for ascertainment of light scattering material which is to be subjected to a laser light beam transmitter fitted with a light scattering means and having attached thereto titration means and tracing means holding a solvent and sample means holding a flavor ingredient or flavor formulation with the occurrence of the titration endpoint taking place at the location of the light scattering means; and associated therewith means for input of data to memory; (ii) means for establishing constraints for:
(a) flavor ingredient or formulation profile;
(b) flavor ingredient or formulation profile on treated product; and
(c) total flavor/solvent solubility and means for input to memory.,
(iii) means for loading a sample syringe with flavor ingredient or flavor formulation and means for loading titrating material into titrant syringe; (iv) means for instructing the setting of the system to reject flavor ingredients having given solvent solubilities and to reject a flavor formulation having a given solvent solubility with the rejection instruction being: S i ≦S A and with the acceptance instruction being: S i >S A wherein S i is the solubility in grams moles per liter of a flavor ingredient and S A is the acceptable solubility of the flavor ingredient; and, in the case of a flavor formulation, with the rejection constraint: [ΣS i ]≦S B and the acceptance constraint: [ΣS i ]>S B ; with associated data input to memory; (v) means for instructing the engagement of sample/titrant syringes simultaneously with engagement of laser light scattering apparatus; (vi) means for instructing acceptance if the endpoint exists at f≧0.2 and means for instructing rejection if the endpoint exists at f<0.2 with associated inputs to memory; (vii) means for instructing acceptance of previously accepted material under the constraint: S i >S A , with associated input to memory; and means for instructing rejection of the sample under the constraint: S i ≦S A , with associated input to memory; (viii) means for instructing the repeating of prior steps (iii), (iv), (v), (vi) and (vii) for different loading rates and for the repetition of creation of different flavor ingredients and flavor formulations; and (ix) means for instructing the carrying out of actual testing for total flavor evaluation with respect to properties of taste and solvent solubility with associated instructions for rejection if not taste acceptable; rejection under the constraint: [ΣS i ]≦S B ; or acceptance if taste acceptable and under the constraint: [ΣS i ]>S B , with associated instructions for reformulation if not taste acceptable whereby steps (iii), (iv), (v), (vi), (vii), (viii) and (ix) are repeated; and wherein f represents the fraction of substance originally in the titrant or sample syringe which is consumed during the titration.
17 . The means for creation of electronic data processing software of claim 15 which utilizes the algorithm:
F
SAT
=
k
2
k
1
k
3
k
2
θ
[
∂
W
∂
θ
]
-
4
π
R
2
[
∂
R
∂
θ
]
wherein F SAT is the concentration of fragrance at saturation in moles per liter; k 1 , k 2 and k 3 are constants; the symbol θ represents time; the symbol
[
∂
W
∂
θ
]
represents the rate of solvent inflow into microglobule, microcapsule, micelle or microparticle at the “endpoint” of the titration; the symbol R represents the average hydration radius of the microglobule, microcapsule, microparticle or micelle formed at the “endpoint” of the titration; and the symbol
[
∂
R
∂
θ
]
represents the rate of change of the microparticle, microglobule, microcapsule or micelle with respect to time.
18 . The means for creation of electronic data processing software of claim 16 which utilizes the algorithm:
F
SAT
=
k
2
k
1
k
3
k
2
θ
[
∂
W
∂
θ
]
-
4
π
R
2
[
∂
R
∂
θ
]
wherein F SAT is the concentration of fragrance at saturation in moles per liter; k 1 , k 2 and k 3 are constants; the symbol θ represents time; the symbol
[
∂
W
∂
θ
]
represents the rate of solvent inflow into microglobule, microcapsule, micelle or microparticle at the “endpoint” of the titration; the symbol R represents the average hydration radius of the microglobule, microcapsule, microparticle or micelle formed at the “endpoint” of the titration; and the symbol
[
∂
R
∂
θ
]
represents the rate of change of the microparticle, microglobule, microcapsule or micelle with respect to time.
19 . The process of claim 1 which is governed by the algorithm:
g
(
θ
)
=
p
(
Γ
)
{
(
-
2
3
KT
θ
[
8
π
n
2
sin
2
[
α
2
]
]
3
η
R
λ
2
)
}
wherein the symbol p(Γ) is decay rate distribution; the symbol Γ is decay rate; the symbol g(θ) is the normalized intensity correlation function; the symbol λ is the scattered light wave length; the symbol α is the scattering angle; the symbol η is the solvent viscosity; the symbol θ is time; n is the refractive index; K is the Boltzmann constant; and T is temperature in degrees Kelvin at the location where the endpoint is determined in the light scattering apparatus.
20 . The process of claim 2 which is governed by the algorithm:
g
(
θ
)
=
p
(
Γ
)
{
(
-
2
3
KT
θ
[
8
π
n
2
sin
2
[
α
2
]
]
3
η
R
λ
2
)
}
wherein the symbol p(Γ) is decay rate distribution; the symbol Γ is decay rate; the symbol g(θ) is the normalized intensity correlation function; the symbol λ is the scattered light wave length; the symbol α is the scattering angle; the symbol θ is the solvent viscosity; the symbol θ is time; n is the refractive index; K is the Boltzmann constant; and T is temperature in degrees Kelvin at the location where the endpoint is determined in the light scattering apparatus.
21 . The process of claim 1 controlled by means of electronic data processing program software.
22 . The process of claim 2 controlled by means of electronic data processing program software.
23 . The process of claim 3 controlled by means of electronic data processing program software.
24 . The process of claim 4 controlled by means of electronic data processing program software.
25 . The process of claim 21 governed by the algorithm:
g
(
θ
)
=
p
(
Γ
)
{
(
-
2
3
KT
θ
[
8
π
n
2
sin
2
[
α
2
]
]
3
η
R
λ
2
)
}
wherein the symbol p(Γ) is decay rate distribution; the symbol Γ is decay rate; the symbol g(θ) is the normalized intensity correlation function; the symbol λ is the scattered light wave length; the symbol α is the scattering angle; the symbol θ is the solvent viscosity; the symbol θ is time; n is the refractive index; K is the Boltzmann constant; and T is temperature in degrees Kelvin at the location where the endpoint is determined in the light scattering apparatus.
26 . The process of claim 22 governed by the algorithm:
g
(
θ
)
=
p
(
Γ
)
{
(
-
2
3
KT
θ
[
8
π
n
2
sin
2
[
α
2
]
]
3
η
R
λ
2
)
}
wherein the symbol p(Γ) is decay rate distribution; the symbol Γ is decay rate; the symbol g(θ) is the normalized intensity correlation function; the symbol λ is the scattered light wave length; the symbol α is the scattering angle; the symbol η is the solvent viscosity; the symbol θ is time; n is the refractive index; K is the Boltzmann constant; and T is temperature in degrees Kelvin at the location where the endpoint is determined in the light scattering apparatus.
27 . The process of claim 23 governed by the algorithm:
g
(
θ
)
=
p
(
Γ
)
{
(
-
2
3
KT
θ
[
8
π
n
2
sin
2
[
α
2
]
]
3
η
R
λ
2
)
}
wherein the symbol p(Γ) is decay rate distribution; the symbol Γ is decay rate; the symbol g(θ) is the normalized intensity correlation function; the symbol λ is the scattered light wave length; the symbol α is the scattering angle; the symbol θ is the solvent viscosity; the symbol θ is time; n is the refractive index; K is the Boltzmann constant; and T is temperature in degrees Kelvin at the location where the endpoint is determined in the light scattering apparatus.
28 . The process of claim 24 governed by the algorithm:
g
(
θ
)
=
p
(
Γ
)
{
(
-
2
3
KT
θ
[
8
π
n
2
sin
2
[
α
2
]
]
3
η
R
λ
2
)
}
wherein the symbol p(Γ) is decay rate distribution; the symbol Γ is decay rate; the symbol g(θ) is the normalized intensity correlation function; the symbol λ is the scattered light wave length; the symbol α is the scattering angle; the symbol θ is the solvent viscosity; the symbol η is time; n is the refractive index; K is the Boltzmann constant; and T is temperature in degrees Kelvin at the location where the endpoint is determined in the light scattering apparatus.
29 . A product produced according to the process of claim 1 .
30 . A product produced according to the process of claim 2 .
31 . A product produced according to the process of claim 3 .
32 . A product produced according to the process of claim 4 .
33 . A product produced according to the process of claim 5 .
34 . A product produced according to the process of claim 6 .
35 . A product produced according to the process of claim 7 .
36 . A product produced according to the process of claim 8 .
37 . A product produced according to the process of claim 9 .
38 . A product produced according to the process of claim 10 .
39 . A product produced according to the process of claim 11 .
40 . A product produced according to the process of claim 12 .
41 . A product produced according to the process of claim 13 .
42 . A product produced according to the process of claim 14 .
43 . A product produced according to the process of claim 19 .
44 . A product produced according to the process of claim 20 .
45 . A product produced according to the process of claim 21 .
46 . A product produced according to the process of claim 22 .
47 . A product produced according to the process of claim 23 .
48 . A product produced according to the process of claim 24 .
49 . A product produced according to the process of claim 25 .
50 . A process for creation of a fragrance formulation comprising the steps of:
(i) selection of two or more fragrance ingredients resulting from information obtained from the electronic data processing software created using the means of claim 15; (ii) determining the relative weight proportions of said ingredients; and (iii) admixing the resulting selected ingredients in the determined weight proportions.
51 . A process for creation of a fragrance formulation comprising the steps of:
(i) selection of two or more fragrance ingredients resulting from information obtained from the electronic data processing software created using the means of claim 16; (ii) determining the relative weight proportions of said ingredients; and (iii) admixing the resulting selected ingredients in the determined weight proportions.
52 . A process for creation of a fragrance formulation comprising the steps of:
(i) selection of two or more fragrance ingredients resulting from information obtained from the electronic data processing software created using the means of claim 17; (ii) determining the relative weight proportions of said ingredients; and (iii) admixing the resulting selected ingredients in the determined weight proportions.
53 . A process for creation of a fragrance formulation comprising the steps of:
(i) selection of two or more fragrance ingredients resulting from information obtained from the electronic data processing software created using the means of claim 18; (ii) determining the relative weight proportions of said ingredients; and (iii) admixing the resulting selected ingredients in the determined weight proportions.
54 . The product produced according to the process of claim 50 .
55 . The product produced according to the process of claim 51 .
56 . The product produced according to the process of claim 52 .
57 . The product produced according to the process of claim 53.Join the waitlist — get patent alerts
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