Device and process for separating magnetic materials from pharmaceutical preparations, their starting or intermediate products, as well as agents that are produced with the aid of said device

Abstract

The invention relates to a device for magnetic separation of pharmaceutical preparations, their starting or intermediate products that contain a separation space, in which a magnetic gradient field prevails and which has an inlet and an outlet, whereby the device is embodied in the form of an attachment filter for injection instruments or infusion instruments.

1 . Device for magnetic separation of pharmaceutical preparations, their starting or intermediate products that contain a separation space, in which a magnetic gradient field prevails and which has an inlet and an outlet, is characterized by the following feature: 
 the device is embodied in the form of an attachment filter for injection instruments or infusion instruments.    
     
     
         2 . Device for magnetic separation of pharmaceutical preparations, their starting or intermediate products that contain a separation space, in which a magnetic gradient field prevails and which has an inlet and an outlet, wherein 
 the device is integrated into injection or infusion instruments.    
     
     
         3 . Device according to one of claims  1  or  2 , wherein 
 the magnetic gradient field in the separation space is generated by a permanent magnet or an electromagnet that is attached outside the separation space.  
 
     
     
         4 . Device according to one of  claims 1  to  3 , wherein 
 the separation space consists of paramagnetic or soft-magnetic material and/or contains paramagnetic or soft-magnetic material.  
 
     
     
         5 . Device according to one of claims  1  or  2 , wherein 
 the gradient field in the separation space is generated by permanent-magnetic material, which forms the separation space or is found in the separation space.  
 
     
     
         6 . Device according to one of claims  1  or  2 , wherein 
 the magnetic gradient field in the separation space is generated by a conductor through which current flows and which is either found in the separation space or surrounds the separation space.  
 
     
     
         7 . Device according to one of claims  5  or  6 , wherein 
 the separation space contains additional paramagnetic or soft-magnetic material.  
 
     
     
         8 . Device according to one of  claims 1  to  7 , wherein 
 the device is sterile.  
 
     
     
         9 . Device for magnetic separation of pharmaceutical preparations, their starting or intermediate products that contain a separation space in which a magnetic gradient field prevails, and which has an inlet and an outlet, wherein 
 the separation space contains one or more soft-magnetic disks that are to be magnetized during separation, which are provided with holes through which the liquid that is to be separated is directed.    
     
     
         10 . Device according to  claim 9 , wherein 
 several disks, whose holes are arranged offset to one another, are located one behind the other in the separation space.    
     
     
         11 . Device according to  claim 9  or  10 , wherein 
 the disks in the upper part of the separation space cannot be magnetized or consist of non-magnetizable material, and the disks in the lower part of the separation space are magnetized by an outer ring magnet or a coil through which current flows.  
 
     
     
         12 . Device according to one of  claims 9  to  11 , wherein 
 the soft-magnetic disks are made from high-grade steel.  
 
     
     
         13 . Process for selective or complete separation of magnetic compounds from pharmaceutical preparations or their starting or intermediate products, wherein 
 the pharmaceutical preparation flows through a device that contains a separation space, in which a magnetic gradient field prevails and which has an inlet and an outlet, and which is embodied in the form of an attachment filter for injection instruments and infusion instruments.    
     
     
         14 . Process for selective or complete separation of magnetic compounds from pharmaceutical preparations or their starting or intermediate products, wherein 
 the pharmaceutical preparation flows through a device that is integrated into injection instruments or infusion instruments.    
     
     
         15 . Process according to  claim 13  or  14 , wherein 
 the magnetic gradient field in the separation space is generated by a permanent magnet or an electromagnet that is attached outside the separation space.  
 
     
     
         16 . Process according to  claim 13 ,  14  or  15 , wherein 
 the separation space consists of paramagnetic or soft-magnetic material and/or contains paramagnetic or soft-magnetic material.  
 
     
     
         17 . Process according to  claim 13  or  14 , wherein 
 the gradient field is generated in the separation space by permanent-magnetic material, which forms the separation space or is found in the separation space.  
 
     
     
         18 . Process according to  claim 13  or  14 , wherein 
 the magnetic gradient field is generated in the separation space by a conductor through which current flows and which either is found in the separation space or surrounds the separation space.  
 
     
     
         19 . Process according to one of claims  17  or  18 , wherein 
 the separation space additionally contains paramagnetic or soft-magnetic material.  
 
     
     
         20 . Process according to one of  claims 13  to  19 , wherein 
 the device is sterile.  
 
     
     
         21 . Process for selective or complete separation of magnetic compounds from pharmaceutical preparations or their starting or intermediate products, wherein 
 the pharmaceutical preparation flows through a device that contains a separation space, in which a magnetic gradient field prevails and which has an inlet and an outlet, and which in addition contains one or more soft-magnetic disks that are to be magnetized during separation, which are provided with holes through which the pharmaceutical preparation is directed.    
     
     
         22 . Process according to  claim 21 , wherein 
 several disks, whose holes are arranged offset to one another, are located one behind the other in the separation space.    
     
     
         23 . Process according to  claim 21  or  22 , wherein 
 the disks in the upper part of the separation space cannot be magnetized or consist of non-magnetizable material, and the disks in the lower part of the separation space are magnetized by an outer ring magnet or a coil through which current flows.  
 
     
     
         24 . Process according to one of  claims 21  to  23 , wherein 
 the soft-magnetic disks are made of high-grade steel.  
 
     
     
         25 . Contrast media for magnetic resonance tomography, that can be obtained by a pharmaceutical preparation based on paramagnetic, superparamagnetic, ferromagnetic, or ferrimagnetic particles being directed through the device according to one of  claims 1  to  12 .  
     
     
         26 . Contrast media for magnetic resonance angiography and/or magnetic resonance lymphography, that can be obtained by a pharmaceutical preparation based on paramagnetic, superparamagnetic, ferromagnetic, or ferrimagnetic particles being directed though a device according to one of  claims 1  to  12 .  
     
     
         27 . Pharmaceutical preparation, from which all foreign particles are removed with the aid of a device according to one of  claims 1  to  8 .  
     
     
         28 . Contrast media, from which metal foreign particles are removed with the aid of a device according to one of  claims 1  to  8 .