US2003108537A1PendingUtilityA1

Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribosee

Priority: Jun 14, 2000Filed: Jan 6, 2001Published: Jun 12, 2003
Est. expiryJun 14, 2020(expired)· nominal 20-yr term from priority
Inventors:Pietro Pola
A61P 9/00A61P 43/00A61P 3/02A61P 21/04A23V 2002/00A61K 31/7004A23L 33/15A23L 33/175A61K 31/205A23L 27/30A61K 45/06A23L 33/13C07H 3/02
40
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Claims

Abstract

A health food/dietary supplement is disclosed suitable for enhancing muscular energy metabolism, comprising as its characterising active ingredients an alkanoyl L-carnitine and ribose.

Claims

exact text as granted — not AI-modified
1 . A food/dietary supplement which comprises the following characterizing ingredients: 
 (a) an alkanoyl L-carnitine selected from the group comprising isovaleryl L-carnitine, propionyl L-carnitine or the pharmacologically acceptable salts thereof or mixtures thereof; and    (b) ribose or a phosphorylate derivative thereof.    
     
     
         2 . The supplement of  claim 1 , further comprising: 
 (c) a “carnitine” selected from the group comprising L-carnitine, acetyl L-carnitine, butyryl L-carnitine and valeryl L-carnitine or the pharmacologically acceptable salts or mixtures thereof.    
     
     
         3 . The supplement of anyone of the preceding claims which further comprises vitamins, sugars, coenzymes, mineral substances, aminoacids, peptides and antioxidants.  
     
     
         4 . The supplement of any of the preceding claims wherein the pharmacologically acceptable salt is selected from the group comprising: chloride; bromide; iodide; aspartate, acid aspartate; citrate, acid citrate; tartrate; phosphate, acid phosphate; fumarate, acid fumarate; glycerophosphate; glucose phosphate; lactate; maleate, acid maleate; mucate; orotate; oxalate; acid oxalate; sulphate, acid sulphate; trichloroacetate; trifluoroacetate and methane sulphonate.  
     
     
         5 . The supplement of any of the preceding claims, for the prevention of myocardial insufficiency and in post-infarct conditions, psychomotor alterations and to cope with the increased muscular energy requirements.  
     
     
         6 . A food/dietary supplement in solid, semi-solid or liquid form.  
     
     
         7 . The food/dietary supplement of any of the preceding claims in the form of tablets, capsules, lozenges, pills, granulates, creams, syrups or drops.  
     
     
         8 . The supplement of any of the preceding claims, wherein the weight ratio of ingredients (a):(b):(c) ranges from 1:1:1 to 1:10:2.  
     
     
         9 . The supplement of  claim 8 , in unit dosage form, comprising:  
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                     
                 
                     
                   Propionyl L-carnitine 
                   125 mg 
                 
                     
                   Acetyl L-carnitine 
                   125 mg 
                 
                     
                   L-carnitine 
                   125 mg 
                 
                     
                   Isovaleryl L-carnitine 
                   125 mg 
                 
                     
                   Ribose 
                   500 mg 
                 
                     
                     
                 
                     
                     
                 
             
                
                
               
               
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         10 . The supplement of  claim 8 , in unit dosage form, comprising:  
       
         
           
                 
                 
                 
                 
               
                     
                     
                 
                     
                     
                 
                     
                   Propionyl L-carnitine 
                   250 
                   mg 
                 
                     
                   Acetyl L-carnitine 
                   250 
                   mg 
                 
                     
                   Isovaleryl L-carnitine 
                   250 
                   mg 
                 
                     
                   L-carnitine 
                   250 
                   mg 
                 
                     
                   Ribose 
                   2 
                   g 
                 
                     
                   Ribonucleic acid 
                   100 
                   mg 
                 
                     
                   Deoxyribonucleic acid 
                   100 
                   mg 
                 
                     
                     
                 
                     
                     
                 
             
                
                
               
               
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         11 . The supplement of  claim 8 , in unit dosage form, comprising:  
       
         
           
                 
                 
                 
                 
               
                     
                     
                 
                     
                     
                 
                     
                   Propionyl L-carnitine 
                   250 
                   mg 
                 
                     
                   Acetyl L-carnitine 
                   250 
                   mg 
                 
                     
                   Isovaleryl L-carnitine 
                   250 
                   mg 
                 
                     
                   L-carnitine 
                   250 
                   mg 
                 
                     
                   Ribose 
                   2 
                   g 
                 
                     
                   L-glutamine 
                   100 
                   mg 
                 
                     
                   L-alanine 
                   100 
                   mg 
                 
                     
                   L-arginine 
                   100 
                   mg 
                 
                     
                   L-glicine 
                   100 
                   mg 
                 
                     
                   L-histidine 
                   100 
                   mg 
                 
                     
                   L-isoleucine 
                   100 
                   mg 
                 
                     
                   L-phenylalanine 
                   50 
                   mg 
                 
                     
                   L-threonine 
                   50 
                   mg 
                 
                     
                   L-serine 
                   100 
                   mg 
                 
                     
                     
                 
                     
                     
                 
             
                
                
               
               
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         12 . The supplement of  claim 8 , in unit dosage form, comprising:  
       
         
           
                 
                 
                 
                 
               
                     
                     
                 
                     
                     
                 
                     
                   Propionyl L-carnitine 
                   250 
                   mg 
                 
                     
                   Acetyl L-carnitine 
                   250 
                   mg 
                 
                     
                   Isovaleryl L-carnitine 
                   250 
                   mg 
                 
                     
                   L-carnitine 
                   250 
                   mg 
                 
                     
                   Ribose 
                   1 
                   g 
                 
                     
                   Glucose-1,6-diphosphate 
                   200 
                   mg 
                 
                     
                   Fructose-1,6-diphosphate 
                   200 
                   mg 
                 
                     
                   Galactose-1,6-phosphate 
                   200 
                   mg 
                 
                     
                   Glycerol-3-phosphate 
                   200 
                   mg 
                 
                     
                   Phosphenylpyruvate 
                   100 
                   mg 
                 
                     
                   Thiamine pyrophosphate 
                   5 
                   mg 
                 
                     
                   Pyridoxal-5-phosphate 
                   5 
                   mg 
                 
                     
                   Magnesium stearate 
                   2 
                   mg 
                 
                     
                     
                 
                     
                     
                 
             
                
                
               
               
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         13 . The supplement of  claim 8 , in unit dosage form, comprising:  
       
         
           
                 
                 
                 
                 
               
                     
                     
                 
                     
                     
                 
                     
                   Propionyl L-carnitine 
                   250 
                   mg 
                 
                     
                   Acetil L-carnitine 
                   250 
                   mg 
                 
                     
                   Isovaleryl L-carnitine 
                   250 
                   mg 
                 
                     
                   L-carnitine 
                   250 
                   mg 
                 
                     
                   Ribose 
                   1 
                   g 
                 
                     
                   Vit. A 
                   1250 
                   U.I. 
                 
                     
                   Vit. B 1   
                   0.5 
                   mg 
                 
                     
                   Vit. B 6   
                   30 
                   mg 
                 
                     
                   Vit. C 
                   50 
                   mg 
                 
                     
                   Vit. E 
                   5 
                   mg 
                 
                     
                   Nicotinamide 
                   25 
                   mg 
                 
                     
                   Vit. B 12   
                   100 
                   mcg 
                 
                     
                   Vit. D 
                   100 
                   U.I. 
                 
                     
                   Pantothenic acid 
                   30 
                   mg 
                 
                     
                   Magnesium glycinate 
                   5 
                   mg 
                 
                     
                   Manganese 
                   1 
                   mg 
                 
                     
                   L-Selenomethionine 
                   50 
                   mcg 
                 
                     
                   Molybdenum 
                   10 
                   mcg 
                 
                     
                   Zinc 
                   1 
                   mg 
                 
                     
                     
                 
                     
                     
                 
             
                
                
               
               
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         14 . A method for the prevention and/or treatment of states of myocardial or skeletal muscle dysfunction related to conditions of anoxia or insufficient energy supply as occurring in coronary or post-infarct disorders or during prolonged physical activity and muscle fatigue, which comprises administering to an individual in need thereof a combination composition comprising the following ingredients: 
 (a) an alkanoyl L-carnitine selected from the group comprising isovaleryl L-carnitine, propionyl L-carnitine or the pharmacologically acceptable salts thereof or mixtures thereof, and    (b) ribose or a phosphorylate derivative thereof.

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