US2003105112A1PendingUtilityA1

Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine

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Priority: Mar 15, 1993Filed: May 10, 2002Published: Jun 5, 2003
Est. expiryMar 15, 2013(expired)· nominal 20-yr term from priority
Inventors:Eric CossementGuy BodsonJean Gobert
A61P 43/00A61P 37/08A61P 29/00A61P 25/20A61P 25/22A61P 11/06C07D 295/26C07D 295/073A61K 31/495C07D 295/088A61P 17/00
56
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Claims

Abstract

Levorotatory and dextrorotatory enantiomers of 1-[(4-chlorophenyl)phenylmethyl)-4-](4-methylphenyl)sulfonyl]piperazine of the formula their preparation and use for the preparation of substantially optically pure enantiomers of 1-[(4-chlorophenyl)phenylmethyl]piperazine, which are themselves valuable intermediate products for the preparation of optically active therapeutic compounds having a very high degree of optical purity.

Claims

exact text as granted — not AI-modified
We claim:  
     
         1 . A method for inhibiting the effects of histamine in a patient which comprises topically applying to the skin or the mucous membrane of the patient an effective amount of substantially optically pure dextrorotatory dihydrochloride of 2-[2-[4-[(4-chlorophenyl)phenylmethyl]- 1 -piperazinyl]ethoxy]ethanol.

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