Relieving symptoms of erectile dysfunction with proanthocyanidins

Abstract

Use of proanthocyanidins as an active ingredient of a stimulator and L-arginine or its salts as a source of nitric oxide in the treatment of erectile dysfunction. The active ingredient stimulates the endothelial NO-synthase enzyme, which acts as a catalyst for the synthesis of nitric oxide from its substrate L-arginine or its salts. The nitric oxide in turn activates the guanylyl cyclase, which leads to an increased development of cyclic guanosine monophosphate, which causes relaxation of smooth muscles. Blood vessel diameter may increase. The stimulator may also have Sildenafil or enzymes that inhibit an enzyme phosphodiesterase type from reducing an amount of the cyclic guanosine monophosphate.

I claim:  
     
         1 . A method of relieving symptoms of erectile dysfunction by stimulating nitric oxide (NO) synthase enzyme and releasing NO, comprising stimulating an endothelial NO-synthase enzyme with proanthocyanidins, effecting synthesis of NO from a substrate that is a source of arginine with the stimulated endothelial NO-synthase enzyme acting a catalyst for the synthesis to release the NO in a therapeutically effective amount sufficient to relieve symptoms of erectile dysfunction.  
     
     
         2 . Ingredients that relieve symptoms of erectile dysfunction by stimulating nitric oxide (NO) synthase enzyme and releasing NO, comprising a substrate that is a source of arginine and subsequently of NO, and proanthocyanidins that are in a therapeutically effective amount to stimulate endothelial NO-synthase enzyme sufficiently so that the stimulated endothelial NO-synthase enzyme serves as a catalyst to enable synthesis of NO from the substrate to release the NO, the substrate being in a therapeutically effective amount to enable the release of the NO in a therapeutically effective amount sufficient to relieve symptoms of erectile dysfunction.