US2003096789A1PendingUtilityA1

Composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer

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Assignee: AVENTIS PHARMA SAPriority: Feb 28, 2000Filed: Sep 18, 2002Published: May 22, 2003
Est. expiryFeb 28, 2020(expired)· nominal 20-yr term from priority
Inventors:Marie-Christine Bissery
A61P 35/00A61P 1/00A61K 31/505A61K 31/4745A61K 31/44A61K 45/06A61K 31/7068
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Claims

Abstract

Therapeutic pharmaceutical compositions comprising a pyrimidine derivative in combination with camptothecin or a camptothecin derivative for the treatment of cancer are described. In one embodiment, the pyrimidine derivative is capecitabine and the camptothecin derivative is CPT-11.

Claims

exact text as granted — not AI-modified
1 . A therapeutic pharmaceutical combination comprising an effective amount of camptothecin or a derivative thereof in combination with an effective amount of a pyrimidine derivative for the treatment of cancer.  
     
     
         2 . A therapeutic pharmaceutical combination comprising an effective amount of CPT-11 in combination with an effective amount of a pyrimidine derivative for the treatment of cancer.  
     
     
         3 . The therapeutic combination according to one of claims  1  or  2 , wherein the pyrimidine derivative is capecitabine.  
     
     
         4 . The therapeutic combination according to one of claims  1  or  2 , wherein the pyrimidine derivative is gemcitabine.  
     
     
         5 . The therapeutic combination according to one of claims  1  or  2 , wherein the pyrimidine derivative is MTA.  
     
     
         6 . The therapeutic combination according to one of claims  1  or  2  wherein the cancer treated is colon cancer.  
     
     
         7 . A therapeutic pharmaceutical combination comprising an effective amount of CPT-11 in combination with an effective amount of capecitabine for the treatment of colon cancer.  
     
     
         8 . A method of treating a cancer by administering to a patient having said cancer an effective amount of camptothecin or a derivative thereof in combination with an effective amount of a pyrimidine derivative.  
     
     
         9 . The method of  claim 8 , wherein the camptothecin derivative is and the pyrimidine derivative is capecitabine.  
     
     
         10 . The method of  claim 9 , wherein CPT-11 and capecitabine are administered semi-simultaneously.  
     
     
         11 . The method of  claim 9 , wherein CPT-11 and capecitabine are administered separately.  
     
     
         12 . The method of  claim 9 , wherein CPT-11 and capecitabine are administered simultaneously.

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