US2003093114A1PendingUtilityA1

Method for effecting hemostasis

57
Priority: Nov 13, 2001Filed: Nov 13, 2001Published: May 15, 2003
Est. expiryNov 13, 2021(expired)· nominal 20-yr term from priority
Inventors:Melvin E. LevinsonGeorge I. GolikErnest ManzanoRaymond Diaz
A61K 31/715A61B 17/0057A61F 13/00A61F 2013/00412A61F 2013/00472A61L 2400/04
57
PatentIndex Score
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Cited by
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References
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Claims

Abstract

A method for effecting hemostasis at a puncture wound, includes applying pressure proximal to the puncture wound, and directing a cationic biopolymer of glucosamine application surface of a closure pad against the puncture wound with force sufficient to prevent fluid from exiting the puncture wound. Then the pressure proximal to the puncture wound is removed and the force on the closure pad is maintained for at least a first predetermined time period. The force on the closure pad is removed if hemostasis is verified. The puncture wound may then be dressed over the closure pad, and the dressing and the closure pad removed after a second predetermined time period.

Claims

exact text as granted — not AI-modified
1 . A method for effecting hemostasis at a puncture wound extending to a blood vessel, comprising: 
 A) applying pressure proximal to the puncture wound in order to at least partially collapse the blood vessel;    B) directing an application surface of a closure pad against the puncture wound with force sufficient to substantially prevent fluid from exiting the puncture wound, wherein the application surface is a cationic biopolymer of glucosamine;    C) removing the pressure proximal to the puncture wound;    D) maintaining the force on the closure pad against the puncture wound for at least a first predetermined time period;    E) removing the force on the closure pad upon verification of hemostasis.    
     
     
         2 . The method of  claim 1 , wherein the entire closure pad including the application surface comprises a cationic biopolymer of glucosamine.  
     
     
         3 . The method of  claim 2 , wherein the biopolymer of glucosamine is poly-N-acetylglucosamine.  
     
     
         4 . The method of  claim 3 , wherein the closure pad is made of non-woven fibers.  
     
     
         5 . The method of  claim 2 , wherein the biopolymer of glucosamine is poly-D-glucosamine.  
     
     
         6 . The method of  claim 5 , wherein the closure pad is made of non-woven fibers.  
     
     
         7 . The method of  claim 2 , wherein the biopolymer of glucosamine is an acetate salt of poly-N-acetylglucosamine.  
     
     
         8 . The method of  claim 7 , wherein the closure pad is made of non-woven fibers.  
     
     
         9 . The method of  claim 2 , wherein the biopolymer of glucosamine is an acetate salt of poly-D-glucosamine.  
     
     
         10 . The method of  claim 9 , wherein the closure pad is made of non-woven fibers.  
     
     
         11 . The method of  claim 2 , wherein the biopolymer of glucosamine is poly-N-acetylglucosamine and poly-D-glucosamine.  
     
     
         12 . The method of  claim 11 , wherein the closure pad is made of non-woven fibers.  
     
     
         13 . The method of  claim 2 , wherein the biopolymer of glucosamine is an acetate salt of poly-N-acetylglucosamine and poly-D-glucosamine.  
     
     
         14 . The method of  claim 13 , wherein the closure pad is made of non-woven fibers.  
     
     
         15 . The method of  claim 1 , wherein the biopolymer of glucosamine is an acetate salt of poly-N-acetylglucosamine and an acetate salt of poly-D-glucosamine.  
     
     
         16 . The method of  claim 15 , wherein the closure pad is made of non-woven fibers.  
     
     
         17 . The method of  claim 2 , wherein the biopolymer of glucosamine is poly-N-acetylglucosamine and an acetate salt of poly-D-glucosamine.  
     
     
         18 . The method of  claim 17 , wherein the closure pad is made of non-woven fibers.  
     
     
         19 . The method of  claim 2 , wherein the application surface comprises a cationic biopolymer of glucosamine and a remainder of the closure pad comprises another material.  
     
     
         20 . The method of  claim 19 , wherein the biopolymer of glucosamine is poly-N-acetylglucosamine.  
     
     
         21 . The method of  claim 20 , wherein the application surface is made of non-woven fibers.  
     
     
         22 . The method of  claim 19 , wherein the biopolymer of glucosamine is poly-D-glucosamine.  
     
     
         23 . The method of  claim 22 , wherein the application surface is made of non-woven fibers.  
     
     
         24 . The method of  claim 19 , wherein the biopolymer of glucosamine is an acetate salt of poly-N-acetylglucosamine.  
     
     
         25 . The method of  claim 24 , wherein the application surface is made of non-woven fibers.  
     
     
         26 . The method of  claim 19 , wherein the biopolymer of glucosamine is an acetate salt of poly-D-glucosamine.  
     
     
         27 . The method of  claim 26 , wherein the application surface is made of non-woven fibers.  
     
     
         28 . The method of  claim 19 , wherein the biopolymer of glucosamine is poly-N-acetylglucosamine and poly-D-glucosamine.  
     
     
         29 . The method of  claim 28 , wherein the application surface is made of non-woven fibers.  
     
     
         30 . The method of  claim 19 , wherein the biopolymer of glucosamine is an acetate salt of poly-N-acetylglucosamine and poly-D-glucosamine.  
     
     
         31 . The method of  claim 30 , wherein the application surface is made of non-woven fibers.  
     
     
         32 . The method of  claim 19 , wherein the biopolymer of glucosamine is an acetate salt of poly-N-acetylglucosamine and an acetate salt of poly-D-glucosamine.  
     
     
         33 . The method of  claim 32 , wherein the application surface is made of non-woven fibers.  
     
     
         34 . The method of  claim 19 , wherein the biopolymer of glucosamine is poly-N-acetylglucosamine and an acetate salt of poly-D-glucosamine.  
     
     
         35 . The method of  claim 34 , wherein the application surface is made of non-woven fibers.  
     
     
         36 . The method of  claim 1 , wherein the first predetermined time period is equal to about ten minutes.  
     
     
         37 . The method of  claim 1 , wherein an introducer having an outer diameter is disposed in the puncture wound and removed from the wound prior to removing the pressure proximal to the wound, and wherein the first predetermined time period is substantially proportional to the diameter of the introducer.  
     
     
         38 . The method of  claim 1 , further comprising: 
 applying a dressing over the closure pad and the puncture wound; and    removing the dressing and the closure pad from the puncture wound after a second predetermined time period.    
     
     
         39 . The method of  claim 38 , wherein the second predetermined time period is equal to about twenty-four hours.  
     
     
         40 . The method of  claim 38 , wherein the dressing includes gauze.

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