Pressurised metered dose inhalers (MDI)

Abstract

The invention relates to the use of pressurised metered dose inhalers (MDIs) having part or all of their internal surfaces consisting of stainless steel, anodised aluminium or lined with an inert organic coating; and to compositions to be delivered with said MDIs.

1 . Pressurised metered dose inhalers containing a solution of an active ingredient in a hydrofluorocarbon propellant, a co-solvent and optionally a low-volatility component characterised in that part or all of the internal surfaces of said inhalers consist of stainless steel, anodised aluminium or are lined with an inert organic coating.  
     
     
         2 . Pressurized metered dose inhalers according to  claim 1 , wherein the active ingredients are selected from β2 agonists, steroids or anti-cholinergic agents and their combinations.  
     
     
         3 . Pressurized metered dose inhalers according to  claim 2 , wherein the active ingredient is ipratropium bromide, oxitropium bromide, tiotropium bromide, flunisolide, triamcinolone acetonide, fluticasone propionate, mometasone furoate, budesonide, ciclesonide, rofleponide and epimers thereof.  
     
     
         4 . Pressurized metered dose inhalers according to any of claims from  1  to  3 , containing a low-volatility component selected from glycerol, polyethylene glycol and isopropyl myristate.  
     
     
         5 . Pressurized metered dose inhalers according to any of claims from  1  to  4 , wherein the co-solvent is ethanol.  
     
     
         6 . Pressurized metered dose inhalers according to any of claims from  1  to  5 , wherein the propellant is selected from HFA 227, HFA 134a and their mixtures.  
     
     
         7 . Pressurised metered dose inhalers according to any of  claims 1  to  6  wherein the inert organic coating is perfluoroalkoxyalkane, epoxy-phenol resin or fluorinated-ethylene-propylene polyether sulfone.  
     
     
         8 . Pressurised metered dose inhalers according to any of  claims 1  to  7  wherein part or all of the internal surfaces are coated with an epoxy phenol resin.  
     
     
         9 . Pressurised metered dose inhalers according to any of  claims 1  to  6  wherein part or all of the internal surfaces consist of anodised aluminium.  
     
     
         10 . Stabilized aerosol solution formulation consisting of an active ingredient in a hydrofluorocarbon propellant, a co-solvent and optionally a low-volatility component for use in a pressurised metered dose inhaler as claimed in any of  claims 1  to  9 .  
     
     
         11 . Aerosol solution formulation of dexbudesonide in a hydrofluorocarbon propellant and ethanol as a co-solvent, further comprising a low volatility compound selected from glycerol, isopropylmyristate and polyethylene glicol.