Analgesic and anti-inflammatory patches for external use containing 4-biphenylylylacetic acid

Abstract

An aqueous hot melted type adhesive base material containing 4-biphenylyl acetic acid (BPAA) is provided. The adhesive base material contains constant amounts of BPAA and has good drug releasability, so that bioavailability of the drug is enhanced. An analgesic and anti-inflammatory external plaster containing BPAA is also provided. The plaster is obtained by dissolving BPAA into an aqueous hot melted type adhesive base material comprising as essential components a styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and water.

1 . An analgesic and anti-inflammatory external plaster containing 4-biphenylyl acetic acid as active ingredient, wherein 4-biphenylyl acetic acid is dissolved into an aqueous hot melted type adhesive base material comprising styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and water as essential components of said hot melt adhesive base material.  
     
     
         2 . An analgesic and anti-inflammatory external plaster containing 4-biphenylyl acetic acid as active ingredient, which obtained by the process comprising the steps of melting and kneading a styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and a softener to form an adhesive base material; adding water and an aqueous solution of BPAA to the adhesive base material at a temperature of 80 to 100° C., while stirring, to form an adhesive base material containing BPAA; coating said base material on a liner; attaching the liner to a base cloth; and cutting the base cloth to a desired size.  
     
     
         3 . The analgesic and anti-inflammatory external plaster according to  claim 1  or  2 , wherein water amount is in a range of 0.1 to 30%.  
     
     
         4 . A process for producing analgesic and anti-inflammatory external plaster containing 4-biphenylyl acetic acid, comprising the steps of melting and kneading a styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and a softener to form an adhesive base; adding water and an aqueous solution of 4-biphenylyl acetic acid to the adhesive base at a temperature of 80 to 100° C., while stirring, to form an adhesive base material containing 4-biphenylyl acetic acid; coating said base material on a liner; laminating the backing; and cutting the backing thus obtained into desired size.