US2003078388A1PendingUtilityA1

Protein purification

Assignee: GENENTECH INCPriority: May 6, 1998Filed: Sep 24, 2002Published: Apr 24, 2003

Est. expiryMay 6, 2018(expired)· nominal 20-yr term from priority

A61P 35/00A61P 43/00C07K 16/2863C07K 16/065C07K 1/18C07K 2317/56C07K 2317/24A61K 38/00A61K 2039/505C07K 16/32C07K 2317/51C07K 2317/21C07K 2317/515

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Claims

Abstract

A method for purifying a polypeptide by ion exchange chromatography is described which involves changing the conductivity and/or pH of buffers in order to resolve a polypeptide of interest from one or more contaminants.

Claims

exact text as granted — not AI-modified

1 . A composition comprising a mixture of humanized anti-HER2 antibody and one or more acidic variants thereof, wherein the amount of the acidic variant(s) is less than about 25% calculated as area under the integrated curve or profile obtained by CSx chromatography.  
     
     
         2 . The composition of  claim 1  further comprising a pharmaceutically acceptable carrier.  
     
     
         3 . The composition of  claim 1  wherein the anti-HER2 antibody is humMAb4D5-8.

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