US2003077332A1PendingUtilityA1

Topical zinc compositions and methods of use

43
Assignee: ALLTERRA INCPriority: Jun 14, 1999Filed: Dec 2, 2002Published: Apr 24, 2003
Est. expiryJun 14, 2019(expired)· nominal 20-yr term from priority
Inventors:Helen Rebecca Godfrey
A61K 33/30A61P 17/00A61P 17/02Y10S424/06A61K 31/198
43
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Claims

Abstract

Compositions including zinc compounds and select amino acids in a carrier base, and methods of skin treatment with such compositions, are described. The compositions are useful for healing skin and minimizing the irritation incurred from contact with the zinc compound without loss of zinc availability during absorption into the integument.

Claims

exact text as granted — not AI-modified
It is claimed:  
     
         1 . A solid or semi-solid composition for topical skin application comprising: 
 a pharmaceutically acceptable carrier base;    at least one zinc compound; and    at least one amino acid; wherein said at least one amino acid is present in an amount corresponding to from approximately 2 to 20 molar equivalents relative to zinc in the composition, said composition contains from about 1 mg to about 20 mg zinc for each gram of said composition, and zinc is released from said composition onto skin to which the composition is applied.    
     
     
         2 . The composition of  claim 1  wherein said at least one amino acid is a monocarboxylic amino acid capable of forming a complex with said at least one zinc compound.  
     
     
         3 . The composition of  claim 1  or  2  wherein said at least one amino acid is glycine, L-lysine, D,L-lysine, or a combination thereof.  
     
     
         4 . The composition of  claim 1  wherein said at least one amino acid is glycine.  
     
     
         5 . The composition of  claim 1  wherein said at least one zinc compound is zinc oxide, Zinc(Amino Acid) 2 , or a combination thereof; and wherein the amino acid is glycine, L-lysine, D,L-lysine, or a combination thereof.  
     
     
         6 . The composition of  claim 1  wherein said at least one zinc compound is zinc oxide and said at least one amino acid is glycine.  
     
     
         7 . The composition of  claim 2  wherein said at least one zinc compound is a complex of divalent zinc with said monocarboxylic amino acid.  
     
     
         8 . The composition of  claim 7  wherein said complex is a zinc glycine complex having a formula Zn(C 2 H 4 NO 2 ) 2 ·nH 2 O in which n has a value of 1, 1½, or 2, combined with from 0.3 to 6.2 parts by weight of anhydrous glycine.  
     
     
         9 . The composition of  claim 7  wherein said complex is a zinc D,L-lysine complex having a formula Zn(C 6 H 13 N 2 O 2 ) 2 ·4H 2 O combined with from 0.9 to 3.5 parts by weight of anhydrous glycine.  
     
     
         10 . The composition of  claim 1  wherein said carrier base is a cream, balm, gel, ointment, emollient, or lotion.  
     
     
         11 . The composition of  claim 1  wherein said composition is present on a skin dressing.  
     
     
         12 . A method of treating skin comprising— 
 (a) applying a zinc compound-containing composition to an area of skin;  
 (b) spreading said composition in a manner that causes said composition to coat said area; and  
 (c) repeating (a) and (b) as necessary;  
 wherein said composition comprises a pharmaceutically acceptable carrier base, at least one zinc compound, and at least one amino acid, wherein said at least one amino acid is present in an amount corresponding to from approximately 2 to 20 molar equivalents relative to zinc, said composition contains from about 1 mg to about 20 mg zinc for each gram of said composition, and zinc is released from said composition onto said area of skin.  
 
     
     
         13 . A method of treating skin comprising— 
 (a) applying a zinc compound-containing composition to a skin dressing; and  
 (b) applying said skin dressing to an area of skin so that said composition is in contact with said area;  
 wherein said composition comprises a pharmaceutically acceptable carrier base, at least one zinc compound, and at least one amino acid, and wherein said at least one amino acid is present in an amount corresponding to from approximately 2 to 20 molecular equivalents relative to zinc, said composition contains from about 1 mg to about 20 mg zinc for each gram of said composition, and zinc is released from said composition onto said area of skin.  
 
     
     
         14 . The method of  claim 12  or  13  wherein said at least one amino acid is a monocarboxylic amino acid capable of forming a complex with said at least one zinc compound.  
     
     
         15 . The method of  claim 12  or  13  wherein said at least one amino acid is glycine, L-lysine, D,L-lysine, or a combination thereof.  
     
     
         16 . The method of  claim 12  or  13  wherein said at least one amino acid is glycine.  
     
     
         17 . The method of  claim 12  or  13  wherein said at least one zinc compound is zinc oxide, Zinc(Amino Acid) 2 , or a combination thereof.  
     
     
         18 . The method of  claim 12  or  13  wherein said at least one zinc compound is zinc oxide and said at least one amino acid is glycine.  
     
     
         19 . The method of  claim 14  wherein said at least one zinc compound is a complex of divalent zinc with said at least one amino acid.  
     
     
         20 . The method of  claim 12  or  13  wherein said carrier base is a cream, balm, gel, ointment, emollient or lotion.

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