Immunointeractive molecules and uses therefor

Abstract

The present invention relates generally to immunointeractive molecules and their use inter alia in the detection and/or purification of T-cell antigen binding molecules (TABMs). The ability to determine the presence and levels of particular TABMs provides a useful diagnostic procedures for a variety of disease conditions.

1 . An isolated monoclonal antibody comprising a portion which is capable of specifically interacting with a T-cell antigen binding molecule (TABM), which monoclonal antibody has the same binding affinity and specificity as monoclonal antibody MG3C9-1A12 produced by hybridoma cell line on deposit with American Type Culture Collection as Accession No. HB-12589.  
     
     
         2 . The monoclonal antibody of  claim 1  wherein the TABM is of animal or avian species.  
     
     
         3 . The monoclonal antibody of  claim 1  wherein the TABM is of mammalian origin.  
     
     
         4 . The monoclonal antibody of  claim 1  wherein the TABM is of human origin.  
     
     
         5 . A hybridoma cell line producing a monoclonal antibody defined according to  claim 1 .  
     
     
         6 . A composition comprising a monoclonal antibody of  claim 1  and one or more pharmaceutically acceptable carriers and/or diluents.  
     
     
         7 . The composition of  claim 6  wherein said monoclonal antibody specifically interacts with a TABM of an animal or avian species.  
     
     
         8 . The composition of  claim 7  wherein said monoclonal antibody specifically interacts with a TABM of a mammalian species.  
     
     
         9 . The composition of  claim 6  wherein said monoclonal antibody specifically interacts with a TABM of a human origin.  
     
     
         10 . An antigen-binding fragment of the isolated monoclonal antibody of  claim 1 .  
     
     
         11 . A composition comprising the antibody-binding fragment of  claim 10  and one or more pharmaceutically acceptable carriers or diluents.  
     
     
         12 . The monoclonal antibody of  claim 1 , wherein said monoclonal antibody is labeled with a reporter molecule capable of producing a detectable signal.  
     
     
         13 . A composition comprising the monoclonal of  claim 12  and one or more pharmaceutically acceptable carriers or diluents.