US2003068677A1PendingUtilityA1
Recombinant production of novel polyketides
Priority: Sep 20, 1993Filed: Mar 12, 2002Published: Apr 10, 2003
Est. expirySep 20, 2013(expired)· nominal 20-yr term from priority
C07D 323/00C12N 15/52C12P 17/06C07D 407/06C12P 17/08C40B 40/00C07D 311/92C07H 17/08C12P 17/162C12P 7/26C07D 309/36C12N 9/93
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Claims
Abstract
Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
Claims
exact text as granted — not AI-modified1 . A method for modifying the acyltransferase active site of a module of a modular polyketide synthase (PKS) comprising replacing a first acyltransferase active site of a PKS with a second acyltransferase active site of the PKS, wherein the PKS is from Saccharopolyspora erythraea.
2 . A method for modifying the acyltransferase domain of a module of a modular polyketide synthase (PKS) comprising modifying a first region encoding a first acyltransferase of a PKS by replacing the first region with a second region encoding a second acyltransferase from a different region of the PKS, wherein the PKS is from Saccharopolyspora erythraea.Join the waitlist — get patent alerts
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