Dosage forms

Abstract

Solid oral dosage forms of controlled substances containing aversive agents are useful in reducing abuse by chewing or inhaling.

We claim:  
     
         1 . An oral pharmaceutical dosage form not susceptible to abuse by respiratory mucosal membrane administration comprising one or more aversive agents.  
     
     
         2 . An oral pharmaceutical dosage form not susceptible to abuse by chewing comprising one or more aversive agents.  
     
     
         3 . An oral pharmaceutical dosage form not susceptible to abuse by respiratory mucosal membrane administration comprising one or more aversive agents and a controlled substance.  
     
     
         4 . An oral pharmaceutical dosage form not susceptible to abuse by chewing comprising one or more aversive agents and a controlled substance.  
     
     
         5 . An oral pharmaceutical dosage form according to  claim 3 , wherein said aversive agent is a respiratory irritant selected from the group consisting of capsaicin, capsacutin dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, homodihydrocapsaicin, capsaicinoids, gingerol, piperine, isopiperine, zingerone, shogaol, and vanyllylamide derivatives, and mixtures thereof.  
     
     
         6 . An oral pharmaceutical dosage form according to  claim 4 , wherein said aversive agent is a bitter substance selected from the group consisting of denatonium benzoate, denatonium capsaicinate, denatonium chloride, denatonium saccharide, limonin, linalool, linalool acetate, naringin, quassin, quercitin, sucrose benzoate, and sucrose octaacetate, and mixtures thereof.  
     
     
         7 . An oral pharmaceutical dosage form according to  claim 5 , wherein said controlled substance is selected from the group consisting of Schedule II, III, IV, and V controlled substances.  
     
     
         8 . An oral pharmaceutical dosage form according to  claim 6 , wherein said controlled substance is selected from the group consisting of Schedule II, III, IV, and V controlled substances.  
     
     
         9 . An oral pharmaceutical dosage form according to  claim 7 , wherein said controlled substance is a Schedule II controlled substance.  
     
     
         10 . An oral pharmaceutical dosage form according to  claim 8 , wherein said controlled substance is a Schedule II controlled substance.