Medicament for treating aseptic inflammations containing anemonin as effective component

Abstract

The present invention discloses a medicament useful for treating aseptic inflammations, containing anemonin as an effective ingredient, and use of an anemonin compound in treating aseptic inflammations. The effective ingredient in the present medicament, anemonin, can be extracted and separated from natural plants containing anemonin or its precursor. The present invention also discloses a method for preparing anemonin extract. The present medicament can be formulated into preparations for oral administration, injection and topical application, especially liquid extract, plaster, suppository, liniment, and paint etc., which can be transdermally absorbed.

1 . A medicament useful for treating aseptic inflammations, which contains a therapeutically effective amount of anemonin.  
     
     
         2 . The medicament as claimed in  claim 1 , wherein the anemonin originates from extract of a natural plant or Chinese herb which contains anemonin or its precursor.  
     
     
         3 . The medicament as claimed in  claim 2 , wherein the natural plant or Chinese herb is selected from the group consisting of Ranunculaceous plants including  Ranunculus japonicus  Thunb.,  Caltha palustris  L.,  Ranunculus sceleratus  L.,  Anemone hupehensis  Lem.,  Pulsatilla chinensis  (Bge.) Regel,  Anemone raddeana  Regel,  Ranunculus Chinensis  Regel,  Anemone altaica  Fisch,  Clematis chinensis  osbeck,  Clematis flnetiana  Ievi et Vant,  Clematis hexapetala  Pall,  Clematis Manshurica  Rupr.,  Clematis paniculata, Clematis florida, Clematis clasiandra  Maxim,  Clematis uncinata  champ.ex Benth,  Clematis meyeniana  Walp, and  Anemone hupehensis  Lem. var.  japonic  (Thunb.) Bowles et Stearn; Graminaceous plants including root of  Imperata cylindrical,  ranunculin-containing plants of Ranunculaceae Helleborus, Anemone, Hepatica, Ranunculus, Bratrachium, and  Aconitum scaposum  var.  vaginatum.    
     
     
         4 . The medicament as claimed in  claim 1 , wherein the anemonin is a chemical synthetic product.  
     
     
         5 . The medicament as claimed in  claim 2 , wherein the anemonin originates from the anemonin extract obtained by extracting a Chinese herb with an organic solvent, water, an animal oil, a vegetable oil, a brewage vinegar or an inorganic acid.  
     
     
         6 . The medicament as claimed in  claim 3 , wherein the anemonin originates from the anemonin extract obtained by extracting a Chinese herb with an organic solvent, water, an animal oil, a vegetable oil, a brewage vinegar or an inorganic acid.  
     
     
         7 . The medicament as claimed in claims  1 - 6 , which further contains any extract of a Chinese herb, which is compatible with the anemonin compound and favorable for the treatment.  
     
     
         8 . The medicament as claimed in claims  1 - 6 , which is a preparation for oral administration, injection, and topical application.  
     
     
         9 . The medicament as claimed in  claim 7 , which is a preparation for oral administration, injection, and topical application.  
     
     
         10 . The medicament as claimed in  claim 8 , wherein the preparation for topical application is a liquid extract, plaster, suppository, liniment or paint, which can be transdermally absorbed.  
     
     
         11 . The medicament as claimed in  claim 9 , wherein the preparation for topical application is a liquid extract, plaster, suppository, liniment or paint, which can be transdermally absorbed.  
     
     
         12 . The medicament as claimed in  claim 1 , wherein the aseptic inflammations comprise cervical spondylosis, lumbar diseases periarthritis humeroscapularis, tennis elbow, muscular fascia syndrome, rheumatic arthritis, osteoarthritis, aseptic prostatitis, multiple neuritis, neurodermatitis, tenosynovitis, lumbar muscle strain; ischias, painful heel, migraine, stubborn stomach-ache, cancerous pain, bronchial asthma, and early necrosis of femoral head caused by aseptic inflammations, and other diseases belong to aseptic inflammations as defined in the medical field.  
     
     
         13 . The medicament as claimed in  claim 2 , wherein the aseptic inflammations comprise cervical spondylosis, lumbar diseases periarthritis humeroscapularis, tennis elbow, muscular fascia syndrome, rheumatic arthritis, osteoarthritis, aseptic prostatitis, multiple neuritis, neurodermatitis, tenosynovitis, lumbar muscle strain; ischias, painful heel, migraine, stubborn stomach-ache, cancerous pain, bronchial asthma, and early necrosis of femoral head caused by aseptic inflammations, and other diseases belong to aseptic inflammations as defined in the medical field.  
     
     
         14 . A naturally originated medicament useful for treating aseptic inflammations, which contains, as an effective ingredient, extract obtained by extracting any natural plant or Chinese herb containing anemonin or its precursor with an organic solvent, water, an animal oil, a vegetable oil, a brewage vinegar or an inorganic acid.  
     
     
         15 . The naturally originated medicament as claimed in  claim 14 , wherein the natural plant or Chinese herb is selected from the group consisting of Ranunculaceous plants including  Ranunculus japonicus  Thunb.,  Caltha palustris  L.,  Ranunculus sceleratus  L.,  Anemone hupehensis  Lem.,  Pulsatilla chinensis  (Bge.) Regel,  Anemone raddeana  Regel,  Ranunculus Chinensis  Regel,  Anemone altaica  Fisch,  Clematis chinensis  osbeck,  Clematis flnetiana  Ievi et Vant,  Clematis hexapetala  Pall,  Clematis Manshurica  Rupr.,  Clematis paniculata, Clematis florida, Clematis clasiandra  Maxim,  Clematis uncinata  champ.ex Benth,  Clematis meyeniana  Walp, and  Anemone hupehensis  Lem. var.  japonic  (Thunb.) Bowles et Stearn; Graminaceous plants including root of  Imperata cylindrical,  ranunculin-containing plants of Ranunculaceae Helleborus, Anemone, Hepatica, Ranunculus, Bratrachium, and  Aconitum scaposum  var.  vaginatum.    
     
     
         16 . The naturally originated medicament as claimed in  claim 14 , wherein the effective ingredient is the extract obtained by extracting the natural plant or Chinese herb with ethanol.  
     
     
         17 . The naturally originated medicament as claimed in  claim 14 , wherein the effective ingredient is the extract obtained by extracting the natural plant or Chinese herb with ethanol.  
     
     
         18 . The naturally originated medicament as claimed in  claim 14 , which further contains an extract of a Chinese herb, which is compatible with the anemonin compound and is favorable for the treatment.  
     
     
         19 . The naturally originated medicament as claimed in  claim 15 , which further contains an extract of a Chinese herb, which is compatible with the anemonin compound and is favorable for the treatment.  
     
     
         20 . The naturally originated medicament as claimed in  claim 14 , which is a preparation for oral administration, injection, and topical application.  
     
     
         21 . The naturally originated medicament as claimed in  claim 15 , which is a preparation for oral administration, injection, and topical application.  
     
     
         22 . The naturally originated medicament as claimed in  claim 20 , wherein the preparation for topical application is a liquid extract, plaster, suppository, liniment or paint, which can be transdermally absorbed.  
     
     
         23 . The naturally originated medicament as claimed in  claim 21 , wherein the preparation for topical application is a liquid extract, plaster, suppository, liniment or paint, which can be transdermally absorbed.  
     
     
         24 . The naturally originated medicament as claimed in  claim 14 , wherein the aseptic inflammations comprise cervical spondylosis, lumbar diseases, periarthritis humeroscapularis, tennis elbow, muscular fascia syndrome, rheumatic arthritis, osteoarthritis, aseptic prostatitis, multiple neuritis, neurodermatitis, tenosynovitis, lumbar muscle strain; ischias, painful heel, migraine, stubborn stomach-ache, cancerous pain, bronchial asthma, and early necrosis of femoral head caused by aseptic inflammations, and other diseases belong to aseptic inflammations as defined in the medical field.  
     
     
         25 . A method for the preparation of a medicament useful for treating aseptic inflammations, which comprises cold-extracting or hot-extracting a natural plant or a Chinese herb containing ranunculin with, as an extractant, an organic solvent, water, an animal oil, a vegetable oil, a brewage vinegar or an inorganic acid under sealed condition, and recovering the resultant extract.  
     
     
         26 . The method as claimed in  claim 25 , wherein the organic solvent is methanol, ethanol, propandiol, glycerine, chloroform or any mixture thereof.  
     
     
         27 . The method as claimed in  claim 25 , where in the cold-extraction is carried out with 30 to 50% strength ethanol for 8 months or more.  
     
     
         28 . The method as claimed in  claim 25 , which comprises heating the extractant 30%-50% strength ethanol to its boiling point, adding the ethanol into a container containing the natural plant or Chinese herb, heating the contents to boiling, and then sealing and storing the container for 6 months or more.  
     
     
         29 . The method as claimed in  claim 25 , which comprises adding 95% strength ethanol as preservative into the pulverized natural plant or Chinese herb to prepare ointment.  
     
     
         30 . The method as claimed in  claim 18 , wherein a preservative is added in conventional amount during the extraction when water is used as the extractant.  
     
     
         31 . A method for treating aseptic inflammations which comprises applying gauze or non-woven fabric absorbed with the medicament as claimed in claims  1 - 6  on the affected or painful sites one dosage per week for 3 weeks, lasting 4 to 6 hours per dosage.  
     
     
         32 . A method for treating aseptic inflammations which comprises applying gauze or non-woven fabric absorbed with the naturally originated medicament as claimed in  claim 14  on the affected or painful sites one dosage per week for 3 weeks, lasting 4 to 6 hours per dosage.  
     
     
         33 . A wet towel useful for treating aseptic inflammations by transdermal absorption, which is prepared by soaking non-woven fabrics with the medicament as claimed in claims  1 - 6 .  
     
     
         34 . A wet towel useful for treating aseptic inflammations by transdermal absorption, which is prepared by soaking non-woven fabrics with the naturally originated medicament as claimed in  claim 14 .  
     
     
         35 . A medicament useful for treating aseptic inflammations, which contains, as an effective ingredient, anemonin crystal obtainable by extracting a natural plant containing anemonin or its precursor, and separating the anemonin crystal in a conventional manner.