Tannate compositions and methods of treatment

Abstract

The present invention is directed to methods and compositions for treating upper respiratory indications, such as the treatment, management or mitigation of cough, cold, cold-like symptoms, symptoms related to upper respiratory infections, influenza symptoms and allergic rhinitis, perennial rhinnitis, nasal and Eustachian tube congestion in an animal by administration of tannate compositions comprising single agent formulations or combinations of at least one or more agents into a single administrative dose.

1 . A composition to treat upper respiratory indications, comprising, a combination of at least one or more therapeutic agents selected from a group comprising antihistamines, decongestants, antitussives, anticholinergics and expectorants, wherein the at least one or more therapeutic agents are tannate salts.  
     
     
         2 . The composition of  claim 1 , wherein the combination comprises an antihistamine, decongestant, and an antitussive.  
     
     
         3 . The composition of  claim 2 , wherein the antihistamine is dexchlorpheniramine tannate or dexbromphenerimine tannate.  
     
     
         4 . The composition of  claim 2 , wherein the antihistamine is dexchlorpheniramine tannate or dexbromphenerimine tannate, the decongestant is pseudoephedrine tannate and the antitussive is dextromethorphane tannate.  
     
     
         5 . The composition of  claim 1 , wherein the therapeutic agent is dexchlorpheniramine tannate or dexbromphenerimine tannate.  
     
     
         6 . The composition of  claim 5 , wherein the decongestant is pseudoephedrine tannate and the expectorant is guaifenesin tannate.  
     
     
         7 . The composition of  claim 1 , wherein the composition is provided in a single administrative dose.  
     
     
         8 . A method of treating upper respiratory indications comprising: 
 administering an effective amount of a pharmaceutically acceptable composition comprising a therapeutic agent free from racemates that is a pharmaceutically acceptable tannate salt.    
     
     
         9 . The method of  claim 8 , wherein the compositions further comprises at least one or more agents selected from selected from a group comprising antihistamines, decongestants, antitussives, anticholinergics and expectorants, wherein the at least one or more agents are tannate compounds.  
     
     
         10 . The method of  claim 9 , wherein the composition comprises an antihistamine, decongestant, and an antitussive.  
     
     
         11 . The method of  claim 9 , wherein the antihistamine is dexchlorpheniramine tannate or dexbrompheniramine tannate, the decongestant is pseudoephedrine tannate and the antitussive is dextromethorphane tannate.  
     
     
         12 . The method of  claim 8 , wherein the composition free of racemates comprises dexchlorpheniramine tannate or dexbrompheniramine tannate.  
     
     
         13 . The method of  claim 12 , wherein the composition further comprises pseudoephedrine tannate.  
     
     
         14 . The method of  claim 12 , wherein the composition further comprises guaifenesin tannate.  
     
     
         15 . The method of  claim 8 , wherein the composition is provided in a single administrative dose.  
     
     
         16 . The method of  claim 9 , wherein the composition is provided in a single administrative dose.  
     
     
         17 . The method of  claim 12 , wherein the composition is provided in a single administrative dose.  
     
     
         18 . The method of  claim 8 , wherein the composition is dexchlorpheniramine tannate.