US2003050439A1PendingUtilityA1

Self-assembling recombinant papilloma virus capsid proteins

53
Priority: Sep 3, 1992Filed: Apr 9, 2001Published: Mar 13, 2003
Est. expirySep 3, 2012(expired)· nominal 20-yr term from priority
Inventors:Douglas R. LowyJohn T. SchillerReinhard Kirnbauer
A61P 31/20A61P 31/12A61P 35/00C12N 2710/20022C12N 2710/20034C12N 7/00A61P 17/12C12N 2710/20023C12N 2800/30C07K 14/005Y10S977/918A01K 2227/10Y10S977/804Y10S977/795Y10S977/927A61K 2039/5258A61K 2039/525Y10S435/975C07K 2319/00A61K 39/00
53
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Claims

Abstract

Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . HPV16 L1 polypeptide, assembled in a capsomeric structure possessing conformational epitopes, made by expression of a recombinant coding sequence in a human.

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