Method of modulating microglial activation for the treatment of acute and chronic neurodegenerative disorders

Abstract

The present invention provides methods of modulating or inhibiting microglia activation comprising the administration of a compound capable of inhibiting 5-LOX, FLAP, attenuating degradation of IκBα or inhibiting nuclear translocation of the NF-κB active complex for the treatment of Alzheimer's disease, brain ischemia, traumatic brain injury, Parkinson's Disease, Multiple Sclerosis, ALS, subarachnoid hemorrhage or other disorders associated with excessive production of inflammatory mediators in the brain.

What is claimed is:  
     
         1 . A method of treating a disorder selected from the group consisting of traumatic brain injury, brain ischemia and subarachanoid hemmorage comprising the administration to a human in need thereof an effective amount of  
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or solvate thereof.