US2003044936A1PendingUtilityA1

Peptide repeat immunogens

40
Priority: Oct 5, 1999Filed: Apr 11, 2002Published: Mar 6, 2003
Est. expiryOct 5, 2019(expired)· nominal 20-yr term from priority
Inventors:Jaulang HwangChia-Tse HsuChun-Jen Ting
C07K 14/21C07K 7/23C07K 2319/00C12N 2710/24122A61P 37/02C07K 14/005A61K 39/00
40
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Claims

Abstract

A polypeptide containing a carrier peptide sequence and a plurality of epitope peptide sequences.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A polypeptide comprising: 
 a carrier peptide sequence, and    a plurality of epitope peptide sequences.    
     
     
         2 . The polypeptide of  claim 1 , wherein the carrier peptide contains a receptor binding domain.  
     
     
         3 . The polypeptide of  claim 2 , wherein the polypeptide contains 2 to 30 copies of the epitope peptide sequence.  
     
     
         4 . The polypeptide of  claim 3 , wherein all copies of the epitope peptide sequence are in a consecutive series.  
     
     
         5 . The polypeptide of  claim 2 , wherein all copies of the epitope peptide sequence are in a consecutive series.  
     
     
         6 . The polypeptide of  claim 2 , wherein the receptor binding domain is that of Pseudomonas exotoxin A.  
     
     
         7 . The polypeptide of  claim 6 , wherein the polypeptide contains 2 to 30 copies of the epitope peptide sequence.  
     
     
         8 . The polypeptide of  claim 7 , wherein all copies of the epitope peptide sequence are in a consecutive series.  
     
     
         9 . The polypeptide of  claim 6 , wherein all copies of the epitope peptide sequence are in a consecutive series.  
     
     
         10 . The polypeptide of  claim 1 , wherein the carrier peptide is a peptide with low immunogenicity.  
     
     
         11 . The polypeptide of  claim 10 , wherein the polypeptide contains 2 to 30 copies of the epitope peptide sequence.  
     
     
         12 . The polypeptide of  claim 11 , wherein all copies of the epitope peptide sequence are in a consecutive series.  
     
     
         13 . The polypeptide of  claim 10 , wherein all copies of the epitope peptide sequence are in a consecutive series.  
     
     
         14 . The polypeptide of  claim 10 , wherein the carrier peptide is glutathione-S-transferase.  
     
     
         15 . The polypeptide of  claim 14 , wherein the polypeptide contains 2 to 30 copies of the epitope peptide sequence.  
     
     
         16 . The polypeptide of  claim 15 , wherein all copies of the epitope peptide sequence are in a consecutive series.  
     
     
         17 . The polypeptide of  claim 14 , wherein all copies of the epitope peptide sequence are in a consecutive series.  
     
     
         18 . The polypeptide of  claim 1 , wherein the polypeptide contains 2 to 30 copies of the epitope peptide sequence.  
     
     
         19 . The polypeptide of  claim 18 , wherein all copies of the epitope peptide sequence are in a consecutive series.  
     
     
         20 . The polypeptide of  claim 1 , wherein all copies of the epitope peptide sequence are in a consecutive series.

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