Platelet activating factor acetylhydrolase, and gene thereof
Abstract
A protein having activities of a human platelet activating factor acetylhydrolase, and represented by an amino acid sequence represented by the following formula (I) or an amino acid sequence having homology therewith; and a DNA encoding the protein: Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val Glu Glu Gly Glu Lys Glu Phe His Val Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Thr Val Phe Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Asn Ile Asp Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe Arg Cys Ala Val Ala Leu Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys Ala Arg Gly Pro Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Gln Thr Asp Phe Ala Phe Val Thr Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asn Gln Trp Asn Asn Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly Ala Pro His His Leu Ser Ser Leu
Claims
exact text as granted — not AI-modified1 . A protein having activities of a human platelet activating factor acetylhydrolase, and represented by an amino acid sequence represented by the following formula (I) or an amino acid sequence having homology therewith:
Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val
Thr Gly Pro His Leu Val Gly Cys Gly Asp Val Met
Glu Gly Gln Asn Leu Gln Gly Ser Phe Phe Arg Leu
Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu
Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr
Gly Leu Ala Glu Tyr Leu Gln Phe Asn Lys Arg Cys
Gly Gly Leu Leu Phe Asn Leu Ala Val Gly Ser Cys
Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr
Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His
Gly Leu Gly Ala Phe Arg Thr Leu Tyr Ser Ala Phe
Cys Met Glu Leu Ala Ser Arg Gly Phe Val Val Ala
Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr
Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro
Thr Asn Glu Ser Leu Gln Glu Glu Trp Ile Pro Phe
Arg Arg Val Glu Glu Gly Glu Lys Glu Phe His Val
Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys
Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala
Gly Gln Thr Val Phe Asn Ile Leu Pro Gly Gly Leu
Asp Leu Met Thr Leu Lys Gly Asn Ile Asp Met Ser
Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala
Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe
Arg Cys Ala Val Ala Leu Asp Ala Trp Met Phe Pro
Leu Glu Arg Asp Phe Tyr Pro Lys Ala Arg Gly Pro
Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met
Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln
His Glu Gln Ser Arg Ile Ile Thr Val Leu Gly Ser
Val His Arg Ser Gln Thr Asp Phe Ala Phe Val Thr
Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr
Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val
Met Val Arg Ala Met Leu Ala Phe Leu Gln Lys His
Leu Asp Leu Lys Glu Asp Tyr Asn Gln Trp Asn Asn
Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly
Ala Pro His His Leu Ser Ser Leu
2 . A DNA encoding said protein of claim 1 .
3 . An expression vector having said DNA of claim 2 .
4 . Recombinant host cells transformed by said expression vector of claim 3 .
5 . A process for the production of a protein having activities of a human platelet activating factor acetylhydrolase, which comprises culturing said recombinant host cells of claim 4 and collecting said protein from the resulting cultured matter.
6 . An antibody against said protein of claim 1 .
7 . A DNA encoding a protein having activities of a bovine platelet activating factor acetylhydrolase, and represented by an amino acid sequence represented by the following formula (III) or an amino acid sequence having homology therewith:
Met Gly Val Asn Gln Ser Val Ser Phe Pro Pro Val
Thr Gly Pro His Leu Val Gly Cys Gly Asp Val Met
Glu Gly Gln Ser Leu Gln Gly Ser Phe Phe Arg Leu
Phe Tyr Pro Cys Gln Glu Ala Glu Glu Thr Ser Glu
Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Ala
Gly Leu Ala Glu Tyr Leu Lys Phe Asn Lys Arg Trp
Gly Gly Leu Leu Phe Asn Leu Gly Val Gly Ser Cys
Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr
Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His
Gly Met Gly Ala Phe Arg Thr Val Tyr Ser Ala Phe
Cys Met Glu Leu Ala Ser Arg Gly Phe Val Val Ala
Val Pro Glu His Arg Asp Gly Ser Ala Ala Ala Thr
Cys Phe Cys Lys Gln Thr Pro Glu Glu Asn Gln Pro
Asp Asn Glu Ala Leu Lys Glu Glu Trp Ile Pro His
Arg Gln Ile Glu Glu Gly Glu Lys Glu Phe Tyr Val
Arg Asn Tyr Gln Val His Gln Arg Val Ser Glu Cys
Val Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala
Gly Gln Ala Val Leu Asn Ile Leu Pro Gly Gly Leu
Asp Leu Met Thr Leu Lys Gly Gly Ile Asp Val Ser
Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala
Thr Ala Ile Leu Ala Leu Ala Lys Glu Met Gln Phe
Arg Cys Ala Val Ala Leu Asp Ala Trp Met Phe Pro
Leu Glu His Asp Phe Tyr Pro Thr Ala Arg Gly Pro
Ile Phe Phe Ile Asn Ala Glu Lys Phe Gln Thr Val
Glu Thr Val Asn Leu Met Lys Lys Ile Cys Asp Gln
His His Gln Ser Arg Ile Ile Thr Val Leu Gly Ser
Val His Arg Ser Leu Thr Asp Phe Val Phe Val Ala
Gly Asn Trp Ile Ser Lys Phe Phe Ser Ser His Thr
Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Thr
Val Val Arg Ala Met Leu Ala Phe Leu Gln Lys His
Leu Asp Leu Lys Glu Asp Tyr Asp Gln Trp Asn Asn
Phe Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly
Ala Pro His His Leu Ser Ser Leu
8 . An expression vector having said DNA of claim 7 .
9 . Recombinant eucaryotic host cells transformed by said expression vector of claim 8 .
10 . A process for the production of a protein having activities of a bovine platelet activating factor acetylhydrolase, which comprises culturing said recombinant eucaryotic host cells of claim 9 and collecting said protein from the resulting cultured matter.
11 . An antibody against a protein having activities of a bovine platelet activating factor acetylhydrolase, and represented by an amino acid sequence represented by the following formula (III) or an amino acid sequence having homology therewith:
Met Gly Val Asn Gln Ser Val Ser Phe Pro Pro Val
Thr Gly Pro His Leu Val Gly Cys Gly Asp Val Met
Glu Gly Gln Ser Leu Gln Gly Ser Phe Phe Arg Leu
Phe Tyr Pro Cys Gln Glu Ala Glu Glu Thr Ser Glu
Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Ala
Gly Leu Ala Glu Tyr Leu Lys Phe Asn Lys Arg Trp
Gly Gly Leu Leu Phe Asn Leu Gly Val Gly Ser Cys
Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr
Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His
Gly Met Gly Ala Phe Arg Thr Val Tyr Ser Ala Phe
Cys Met Glu Leu Ala Ser Arg Gly Phe Val Val Ala
Val Pro Glu His Arg Asp Gly Ser Ala Ala Ala Thr
Cys Phe Cys Lys Gln Thr Pro Glu Glu Asn Gln Pro
Asp Asn Glu Ala Leu Lys Glu Glu Trp Ile Pro His
Arg Gln Ile Glu Glu Gly Glu Lys Glu Phe Tyr Val
Arg Asn Tyr Gln Val His Gln Arg Val Ser Glu Cys
Val Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala
Gly Gln Ala Val Leu Asn Ile Lue Pro Gly Gly Leu
Asp Leu Met Thr Leu Lys Gly Gly Ile Asp Val Ser
Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala
Thr Ala Ile Leu Ala Leu Ala Lys Glu Met Gln Phe
Arg Cys Ala Val Ala Leu Asp Ala Trp Met Phe Pro
Leu Glu His Asp Phe Tyr Pro Thr Ala Arg Gly Pro
Ile Phe Phe Ile Asn Ala Glu Lys Phe Gln Thr Val
Glu Thr Val Asn Leu Met Lys Lys Ile Cys Asp Gln
His His Gln Ser Arg Ile Ile Thr Val Leu Gly Ser
Val His Arg Ser Leu Thr Asp Phe Val Phe Val Ala
Gly Asn Trp Ile Ser Lys Phe Phe Ser Ser His Thr
Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Thr
Val Val Arg Ala Met Leu Ala Phe Leu Gln Lys His
Leu Asp Leu Lys Glu Asp Tyr Asp Gln Trp Asn Asn
Phe Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly
Ala Pro His His Leu Ser Ser LeuJoin the waitlist — get patent alerts
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