US2003036799A1PendingUtilityA1

TRAP-coated bone grafts and prostheses

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Assignee: WASHINGTON RES FOUNDPriority: Apr 22, 1997Filed: Sep 27, 2002Published: Feb 20, 2003
Est. expiryApr 22, 2017(expired)· nominal 20-yr term from priority
Inventors:Minako Yoshioka LeeDavid R. EyreMary Ann Eklof Weis
A61P 19/00A61F 2002/2835A61L 2300/412A61L 2300/252A61L 24/02A61F 2/30A61F 2002/4631A61F 2310/00293A61L 31/16A61L 2300/606A61L 27/54A61L 27/12A61F 2/30767A61L 31/026A61L 24/0015A61L 2300/254A61L 2430/02
51
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Claims

Abstract

A composition or device suitable for orthopedic or dental implantation to bone, characterized by tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum.

Claims

exact text as granted — not AI-modified
The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:  
     
         1 . A composition suitable for medical implantation comprising tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum.  
     
     
         2 . A bone graft composition according to  claim 1 .  
     
     
         3 . The bone graft composition of  claim 2 , wherein the hydroxyapatite substratum is selected from among autologous bone, cadaveric allograft bone, and coralline hydroxyapatite.  
     
     
         4 . The bone graft composition of  claim 2 , wherein the TRAP is adsorbed throughout the porous hydroxyapatite substratum.  
     
     
         5 . The bone graft composition of  claim 2 , wherein the TRAP is adsorbed to only the outer surface of the porous hydroxyapatite substratum.  
     
     
         6 . A bone cement composition according to  claim 1 , comprising tartrate-resistant acid phosphatase (TRAP) adsorbed to a particulate hydroxyapatite substratum admixed in a curable acrylic polymer.  
     
     
         7 . A prosthetic device having an outer bone attachment surface comprising tartrate-resistant acid phosphatase (TRAP) adsorbed to a hydroxyapatite substratum.  
     
     
         8 . The prosthetic device of  claim 5 , wherein the TRAP is adsorbed to the outer approximately 10 microns of the hydroxyapatite substratum.  
     
     
         9 . The prosthetic device of  claim 5 , selected from among an artificial joint and an artificial tooth.  
     
     
         10 . An orthopedic attachment device having a bone contacting surface comprising tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum.  
     
     
         11 . The orthopedic attachment device of  claim 10 , selected from among a screw, a staple, a pin, a bolt, and a plate.

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