Pharmaceutical composition comprising fenofibrate

Abstract

The bioavailability of fenofibrate is improved by making a solid dispersion of a disentegrant in the fenofibrate. Method of making said solid dispersion comprising melting the fenofibrate, blending the disintegrant into the melt, and resolidifying the mixture.

What is claimed is:  
     
         1 . A solid pharmaceutical composition comprising a solid dispersion of a disintegrant in fenofibrate.  
     
     
         2 . A composition as in  claim 1  wherein the disintegrant is selected from croscarmellose sodium, sodium starch glycolate and crospovidone.  
     
     
         3 . A process of making a composition as in either of claims  1  or  2 , which comprises the steps of melting the fenofibrate, blending the disintegrant into the molten fenofibrate, and solidifying the mixture.  
     
     
         4 . A process as in  claim 3  which further comprises the steps of grinding the resulting solid into granules and further processing the granules into capsules or tablets.