Periodontal regeneration composition and method of using same

Abstract

A periodontal structure regeneration composition for treatment of periodontal disease is a mixture of particles of a bone growth material and collagen. All particles are sized to be less than 1 mm in diameter. The periodontal regeneration composition is injected into the periodontal pocket through an 18 gauge needle. The composition is available in pre-filled syringes offered in a kit that may also contain strips of surgical sponge or gauze that are sized to fit within a periodontal pocket, a tube of adhesive, a dental bur, a probe, a gauze placement tool, gauze counter and a brush for cleaning the dental bur.

I claim:  
     
         1 . A periodontal structure regeneration composition for treatment of periodontal disease comprising a mixture of particles of a bone growth material and collagen less than 1 mm in diameter, all particles sized to enable the composition to be injected into a periodontal pocket through an 18 gauge needle.  
     
     
         2 . The composition of  claim 1  wherein the collagen is in a form selected from the group consisting of particles, fibrils and gels.  
     
     
         3 . The composition of  claim 1  also comprising at least one growth factor, nutrient factor, drug, calcium containing compound, anti-inflammatory agent, anti-microbial agent, root treatment material or combination thereof.  
     
     
         4 . The composition of  claim 1  wherein the bone growth material is at least one of human bone particles, hydroxylapatite, bovine bone particles, ground coral and calcium sulfate.  
     
     
         5 . The composition of  claim 1  wherein the mixture is placed within a periodontal pocket and further comprising an adhesive placed over a portion of the mixture.  
     
     
         6 . The composition of  claim 5  wherein the mixture also comprises at least one growth factor, nutrient factor, drug, calcium containing compound, anti-inflammatory agent, anti-microbial agent, antibiotic, root treatment, bone morphogenic protein, dental matrix derivative or combination thereof.  
     
     
         7 . The composition of  claim 5  wherein the bone growth material is at least one of human bone particles, bone chips and hydroxylapatite, bovine bone particles, ground coral and calcium sulfate.  
     
     
         8 . A method of treating periodontal disease comprising: 
 placing a sponge into a periodontal pocket to distend the pocket and to cause hemostasis;    removing the sponge; and    injecting into the periodontal pocket a mixture of a bone growth material and collagen;    all done without incisions in gingival tissue surrounding the periodontal pocket.    
     
     
         9 . The method of  claim 8  in which the method is performed without removing any significant existing bone, gingiva, or granulation tissue.  
     
     
         10 . The method of  claim 8  also comprising placing an adhesive over the periodontal pocket after injecting the mixture.  
     
     
         11 . The method of  claim 10  wherein the adhesive is selected from the group comprising water curable adhesives, visible light curable adhesives, auto curing adhesives, heat cured adhesives, reactive-component cure adhesives, surface activated adhesives and curable adhesives that cure when exposed to ultraviolet radiation.  
     
     
         12 . The method of  claim 11  wherein the adhesive is water curable.  
     
     
         13 . The method of  claim 12  also comprising placing water on the adhesive after the adhesive has been placed.  
     
     
         14 . The method of  claim 13  wherein the water contains a dye.  
     
     
         15 . The method of  claim 8  wherein the mixture is injected through a syringe having a needle not larger than 18 gauge.  
     
     
         16 . The method of  claim 8  also comprising the step of abrading at least a portion of a tooth and inner surface of gingiva and leaving the abraded material in the pocket.  
     
     
         17 . The method of  claim 8  wherein the sponge contains at least one antibacterial chemical.  
     
     
         18 . The method of  claim 17  wherein the antibacterial chemical is selected from the group consisting of peroxide, chlorhexadine, iodine and triiodomethane.  
     
     
         19 . The method of  claim 8  wherein the sponge is impregnated with at least one of epinephrine, alum, aluminum sulfate, aluminum, potassium sulfate, collagen, aluminum chloride, oxyguinol sulfate.  
     
     
         20 . The method of  claim 8  wherein the mixture also contains at least one growth factor, nutrient factor, drug, calcium containing compound, anti-inflammatory agent, anti-microbial agent, antibiotic, root treatment material, bone morphogenic protein, dental derivatve or combination thereof.  
     
     
         21 . The method of  claim 8  wherein bleeding occurs and further comprising applying butyl cyanoacrylate over bleeding sites to stop the bleeding.  
     
     
         22 . The method of  claim 8  wherein bleeding occurs and further comprising applying the mixture of bone growth material and collagen over bleeding sites to stop the bleeding.  
     
     
         23 . A kit for use in treating periodontal disease comprising: 
 a mixture of bone growth material and collagen, the mixture containing particles sufficiently small and being of a consistency suitable for injection through an 18 gauge needle;    a syringe having a needle diameter not larger than 18 gauge; and    at least one sponge or gauze strip.    
     
     
         24 . The kit of  claim 23  also comprising a gauze placement tool.  
     
     
         25 . The kit of  claim 23  also comprising at least one dental bur.  
     
     
         26 . The kit of  claim 25  wherein the dental bur has a tip that tapers to a rounded end.  
     
     
         27 . The kit of  claim 25  wherein the at least one dental bur is a plurality of dental burs of different sizes and each dental bur is color coded to identify size of the bur.  
     
     
         28 . The kit of  claim 23  wherein the mixture also comprises at least one growth factor, nutrient factor, drug, calcium containing compound, anti-inflammatory agent, anti-microbial agent, antibiotic, root treatment material, bone morphogenic protein, dental matrix derivative or combination thereof.  
     
     
         29 . The kit of  claim 23  wherein the bone growth material is at least one of human bone particles, bovine bone particles, ground coral, hydroxylapatite and calcium sulfate.  
     
     
         30 . The kit of  claim 23  also comprising a gauze counter.