Compositions comprising a mixture of bioflavonols

Abstract

The present invention relates to novel compositions containing a mixture of two or three bioflavonols like isoquercetin, quercetin-4′-glycoside, rutin and quercetin, which show differences in their pharmacokinetics. These compositions are useful as food supplements possessing preventive properties against damage to human tissues due to their antioxidant properties. Furthermore, these compositions secure a continuum of the presence of bioflavonols having the same aglycone in human plasma over an extended period of time.

1 . Orally applicable composition comprising a mixture of the bioflavonols isoquercetin (quercetin-3-glucoside) or quercetin-4′-glucoside and rutin, optionally together with quercetin.  
     
     
         2 . Composition according to  claim 1  comprising as flavonols isoquercetin and rutin.  
     
     
         3 . Composition according to  claim 2  comprising isoquercetin and rutin in a molar ratio of about 1:4.  
     
     
         4 . Composition according to  claim 3  characterised in that it maintains the very similar concentrations of flavonols in plasma up to 24 hours assuring similar pharmacological and nutraceutical activity, when administered to humans.  
     
     
         5 . Composition according to  claim 1  comprising isoquercetin or quercetin-4′-glycoside, quercetin and rutin.  
     
     
         6 . Composition according to  claim 5  comprising isoquercetin or quercetin-4′-glycoside, quercetin and rutin in a molar ration of about 1:1,5:3.  
     
     
         7 . Composition according to  claim 6  characterised in that it maintains the very similar concentrations of flavonols in plasma up to 48 hours assuring similar pharmacological and nutraceutical activity, when administered to humans.  
     
     
         8 . Method of maintaining a continued presence of high concentrations of bioflavonols in human plasma for an extended period of time which comprises orally administering a composition according to  claim 1 .  
     
     
         9 . Method of protection against oxidative damage to human organs, tissues and cells which comprises orally administering a composition according to  claim 1 .  
     
     
         10 . Method of supporting a pharmacological treatment of a disease or dysfunction caused by oxidative damage, which comprises orally administering a composition according to  claim 1 .  
     
     
         11 . A method of using the composition according to  claim 1  which comprises employing the composition of  claim 1  as a food supplement.  
     
     
         12 . Pharmaceutical composition containing a pharmaceutically active ingredient, a pharmaceutically acceptable carrier and a composition according to  claim 1.