Stabilized cefuroxime axetil

Abstract

Solid pharmaceutical compositions comprising cefuroxime axetil as active ingredient and a zinc salt as stabilizer.

What is claimed is:  
     
         1 . A solid pharmaceutical composition comprising cefuroxime axetil and a zinc salt.  
     
     
         2 . A composition of  claim 1 , wherein the zinc salt is zinc chloride.  
     
     
         3 . A composition of  claim 1  or  2 , wherein the amount of zinc salt is from about 0.1 part to about 4 parts per 100 parts cefuroxime axetil by weight.  
     
     
         4 . A composition of  claim 1  or  2 , wherein the amount of zinc salt is from about 0.2 to about 2 parts per 100 parts cefuroxime axetil by weight.  
     
     
         5 . A composition of  claim 1  or  2 , wherein the amount of zinc salt is about 1 part per 100 parts cefuroxime axetil by weight.  
     
     
         6 . A composition of any of  claims 1  to  5 , in the form of a tablet.  
     
     
         7 . A composition of any of  claims 1  to  5 , in the form of powder or granules for oral suspension.  
     
     
         8 . A process of stabilization of cefuroxime axetil comprising the step of addition of a zinc salt to the cefuroxime axetil.  
     
     
         9 . A process of  claim 8 , wherein the cefuroxime axetil and zinc salt are both dissolved in solvent and the solvent is evaporated.  
     
     
         10 . A process of  claim 8  or  9 , wherein the zinc salt is zinc chloride.