Dermatological compositions and methods

Abstract

Dermatological compositions (methods of making and using) that include one or more anesthetic agents and/or one or more anti-inflammatory agents and/or a combination of ammonium, sodium, and potassium salts, preferably of an alpha-hydroxy acid.

What is claimed is:  
     
         1 . A dermatologic composition comprising: 
 at least one acid, amide, ester, or salt selected from the group consisting of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof;    at least one anti-inflammatory agent;    at least one ammonium salt; and    at least one metal ion salt.    
     
     
         2 . A dermatologic composition comprising: 
 at least one acid, amide, ester, or salt selected from the group consisting of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof;    at least one anti-inflammatory agent; and    at least one anesthetic agent.    
     
     
         3 . A dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one salt of an alpha-hydroxy acid;    at least one steroid anti-inflammatory agent;    at least one ammonium salt; and    at least one metal ion salt.    
     
     
         4 . A dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one ammonium salt of an alpha-hydroxy acid;    at least one potassium salt of an alpha-hydroxy acid;    at least one sodium salt of an alpha-hydroxy acid; and    at least one steroid anti-inflammatory agent; 
 wherein the alpha-hydroxy acid is of the formula R—CH(OH)—COOH, wherein R is hydrogen or a C 1  to C 5  alkyl group.  
   
     
     
         5 . A dermatologic composition comprising: 
 at least one alpha-hydroxy acid, ester thereof, amide thereof, and combinations thereof;    at least one ammonium salt of an alpha hydroxy acid; and    at least one steroid anti-inflammatory agent; 
 wherein the at least one alpha-hydroxy acid, ester thereof, amide thereof, or combinations thereof is present in the composition in an amount of about 8% to about 15% by weight, and the at least one ammonium salt of an alpha-hydroxy acid is present in the composition in an amount of about 15.9% to about 29.6% by weight.  
   
     
     
         6 . A method for preparing a dermatologic composition, the method comprising combining at least one anti-inflammatory agent with at least one acid, amide, ester, or salt selected from the group consisting of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof, at least one ammonium salt, and at least one metal ion salt to form a dermatologic composition.  
     
     
         7 . A method for preparing a dermatologic composition comprising: 
 providing at least one alpha-hydroxy acid;    neutralizing at least a portion of the alpha-hydroxy acid with ammonium hydroxide in an aqueous solution to form a neutralized acid solution; and    adding at least one anti-inflammatory agent to the neutralized acid solution.    
     
     
         8 . A method of reducing inflammation of the skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one acid, amide, ester, or salt selected from the group consisting of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof;    at least one anti-inflammatory agent;    at least one ammonium salt; and    at least one metal ion salt.    
     
     
         9 . A method of reducing inflammation of the skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one salt of an alpha-hydroxy acid;    at least one steroid anti-inflammatory agent;    at least one ammonium salt; and    at least one metal ion salt.    
     
     
         10 . A method of reducing inflammation of the skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one acid, amide, ester, or salt selected from the group consisting of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof;    at least one anti-inflammatory agent; and    at least one anesthetic agent.    
     
     
         11 . A method of reducing inflammation of the skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one salt of an alpha-hydroxy acid;    at least one steroid anti-inflammatory agent; and    at least one anesthetic agent.    
     
     
         12 . A method of reducing inflammation of the skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one ammonium salt of an alpha-hydroxy acid;    at least one potassium salt of an alpha-hydroxy acid;    at least one sodium salt of an alpha-hydroxy acid; and    at least one steroid anti-inflammatory agent;    wherein the alpha-hydroxy acid is of the formula R—CH(OH)—COOH, wherein R is hydrogen or a C 1  to C 5  alkyl group.    
     
     
         13 . A dermatologic composition comprising: 
 at least one acid, amide, ester, or salt selected from the group consisting of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof;    at least one anesthetic agent;    at least one ammonium salt; and    at least one metal ion salt.    
     
     
         14 . A dermatologic composition comprising: 
 at least one acid, amide, ester, or salt selected from the group consisting of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof;    at least one anesthetic agent; and    at least one anti-foaming agent.    
     
     
         15 . A dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one salt of an alpha-hydroxy acid;    at least one anesthetic agent; and    at least one anti-foaming agent.    
     
     
         16 . A dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one salt of an alpha-hydroxy acid;    at least one anesthetic agent;    at least one ammonium salt; and    at least one metal ion salt.    
     
     
         17 . A dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one ammonium salt of an alpha-hydroxy acid;    at least one potassium salt of an alpha-hydroxy acid;    at least one sodium salt of an alpha-hydroxy acid; and    at least one anesthetic agent; 
 wherein the alpha-hydroxy acid is of the formula R—CH(OH)—COOH, wherein R is hydrogen or a C 1  to C 5  alkyl group.  
   
     
     
         18 . A method for preparing a dermatologic composition, the method comprising combining at least one anesthetic agent with at least one acid, amide, ester, or salt selected from the group of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof, at least one ammonium salt, and at least one metal ion salt, to form a dermatologic composition.  
     
     
         19 . A method for preparing a dermatologic composition, the method comprising: 
 providing at least one alpha-hydroxy acid;    neutralizing at least a portion of the alpha-hydroxy acid with ammonium hydroxide in an aqueous solution to form a neutralized acid solution; and    adding at least one anesthetic agent to the neutralized acid solution.    
     
     
         20 . A method of reducing itching and/or pain of the skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one acid, amide, ester, or salt selected from the group consisting of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof;    at least one anesthetic agent;    at least one ammonium salt; and    at least one metal ion salt.    
     
     
         21 . A method of reducing itching and/or pain of the skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one acid, amide, ester, or salt selected from the group consisting of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof;    at least one anesthetic agent; and    at least one anti-foaming agent.    
     
     
         22 . A method of reducing itching and/or pain of the skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one salt of an alpha-hydroxy acid;    at least one anesthetic agent; and    at least one anti-foaming agent.    
     
     
         23 . A method of reducing itching and/or pain of the skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one salt of an alpha-hydroxy acid;    at least one anesthetic agent;    at least one ammonium salt; and    at least one metal ion salt.    
     
     
         24 . A method of reducing itching and/or pain of the skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one alpha-hydroxy acid;    at least one ammonium salt of an alpha-hydroxy acid;    at least one potassium salt of an alpha-hydroxy acid;    at least one sodium salt of an alpha-hydroxy acid; and    at least one anesthetic agent; 
 wherein the alpha-hydroxy acid is of the formula R—CH(OH)—COOH, wherein R is hydrogen or a C 1  to C 5  alkyl group.  
   
     
     
         25 . A dermatologic composition comprising: 
 at least one alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof;    at least one ammonium salt of an alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof;    at least one potassium salt of an alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof; and    at least one sodium salt of an alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof.    
     
     
         26 . A method for preparing a dermatologic composition, the method comprising combining at least one alpha-hydroxy acid, at least one ammonium salt of an alpha-hydroxy acid, at least one sodium salt of an alpha-hydroxy acid, and at least one potassium salt of an alpha-hydroxy acid to form a dermatological composition.  
     
     
         27 . A method of treating a skin disorder of a subject, the method comprising contacting the subject's skin with a dermatologic composition comprising: 
 at least one alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof;    at least one ammonium salt of an alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof;    at least one potassium salt of an alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof; and    at least one sodium salt of an alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof.    
     
     
         28 . A method for preparing a dermatologic composition, the method comprising contacting a composition comprising an ammonium salt of an alpha-hydroxy acid with activated charcoal.  
     
     
         29 . A method for preparing a dermatologic composition, the method comprising: 
 neutralizing an alpha-hydroxy acid with ammonium hydroxide in an aqueous solution to form a neutralized acid solution; and    contacting the neutralized acid solution with activated charcoal to provide a deodorized neutralized acid solution.    
     
     
         30 . A dermatologic composition comprising: 
 ammonium lactate;    lactic acid in an amount of about 1% by weight to about 30% by weight as a free acid;    pramoxine HCl in an amount of about 0.5% to about 20% by weight; and    an anti-foaming agent.    
     
     
         31 . A dermatologic composition comprising: 
 ammonium lactate;    lactic acid in an amount of about 1% by weight to about 30% by weight as a free acid;    pramoxine HCl in an amount of about 0.5% to about 20% by weight;    a dimethylsiloxane polymer in an amount of about 0.25% by weight to about 3% by weight;    at least one non-ionic surfactant selected from the group consisting of glyceryl stearate, PEG 100-stearate, polyoxyl-20-cetostearyl ether, glyceryl monooleate, glyceryl palmitostearate, self-emulsifying wax, polyoxyl-20-stearate, polyoxyl-40-stearate, polyoxyl-60-stearate, polyoxyl-80-stearate, polyoxyl-20-oleate, polyoxyl-40-oleate, polyoxyl-60-oleate, polyoxyl-80-oleate, polyoxyl-20-palmitate, polyoxyl-40-palmitate, polyoxyl-60-palmitate, polyoxyl-80-palmitate, laureth-2, laureth-4, laureth-6, laureth-8, and combinations thereof;    at least one thickener selected from the group consisting of methyl cellulose, hydroxypropyl methyl cellulose, ethyl cellulose, cetyl alcohol, cetostearyl alcohol, stearyl alcohol, magnesium aluminum silicate, xanthan gum, aluminum magnesium silicate, tribeneonite, kaolin, magnesium trisilicate, monemorillonite, saeonite, stearic acid, talc, and combinations thereof;    at least one emollient selected from the group consisting of glycerin 99.5%, glycerin 95%, glycerin 85%, cetyl alcohol, light mineral oil, medium mineral oil, heavy mineral oil, and combinations thereof;    at least one humectant selected from the group consisting of glycerin 99.5%, glycerin 95%, glycerin 85%, propylene glycol, butylene glycol, and combinations thereof;    at least one preservative selected from the group consisting of methylparaben, ethylparaben, propylparaben, propylparaben potassium salt, propylparaben sodium salt, butylparaben, and combinations thereof; and    water.    
     
     
         32 . A dermatologic composition comprising: 
 ammonium lactate in an amount of about 15.9% by weight to about 29.6% by weight;    lactic acid in an amount of about 1% to about 30% by weight as a free acid;    hydrocortisone acetate in an amount of about 0% by weight to about 2.5% by weight;    pramoxine HCl an amount of about 0% by weight to about 20% by weight;    a dimethylsiloxane polymer in an amount of about 0% by weight to about 3% by weight;    laureth-4 in an amount of about 0.5% to about 3% by weight;    propylparaben in an amount from about 0.01% to about 1% by weight;    cetyl alcohol in an amount of about 0.2% by weight to about 5% by weight.    polyoxyl-40-stearate in an amount of about 0.5% to about 5% by weight;    a blend of glyceryl stearate and PEG-100 stearate, wherein the blend of glyceryl stearate and PEG-100 stearate is present in an amount of about 2% to about 5.5% by weight;    propylene glycol in an amount of about 1% to about 15% by weight;    light mineral oil in an amount of about 1% to about 20% by weight;    magnesium aluminum silicate in an amount of about 0.5% to about 10% by weight;    methyl cellulose in an amount of about 0.0001% to about 1% by weight;    glycerin 99.5% in an amount of about 1% to about 10% by weight;    methylparaben in an amount from about 0.02% to about 1% by weight; and    water in an amount of about 40% to about 50% by weight.    
     
     
         33 . A dermatologic composition comprising: 
 at least one acid, amide, ester, or salt selected from the group consisting of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, an ester thereof, an amide thereof, a salt thereof, and combinations thereof;    at least one potassium salt; and    at least one sodium salt; 
 wherein the sodium salt is present in the composition in an amount of about 1% by weight to about 30% by weight; and the potassium salt is present in the composition in an amount of about 1% by weight to about 30% by weight.  
   
     
     
         34 . A dermatologic composition comprising: 
 at least one alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof; and    at least two salts selected from the group consisting of:    an ammonium salt of an alpha hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof;    a potassium salt of an alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof; and    a sodium salt of an alpha-hydroxy acid, beta-hydroxy acid, alpha-keto acid, or combinations thereof.    
     
     
         35 . A dermatological composition comprising: 
 ammonium lactate in an amount of about 10% to about 15% by weight;    potassium lactate in an amount of about 3% to about 7% by weight; and    sodium lactate in an amount of about 3% to about 7% by weight.