Paroxetine tablets & capsules

Abstract

Methods for preparing a wet granule formulation of paroxetine hydrochloride are disclosed. The formulations are suitable for tabletting and capsulation.

1 . An aqueous or aqueous/alcohol solution of paroxetine which contains at least 75 mg paroxetine/ml.  
     
     
         2 . The solution of  claim 1  which contains at least 200 mg/ml of paroxetine.  
     
     
         3 . The solution of  claim 2  which contains at least 300 mg/ml of paroxetine.  
     
     
         4 . The solution of  claim 3  which further contains at least one acidulent and at least one water dispersible polymer.  
     
     
         5 . The solution of  claim 4  which contains ethanol up to a concentration of 25% v/v.  
     
     
         6 . A method to prepare a solution with a high concentration of paroxetine which method comprises dissolving paroxetine hydrochloride amorphous in water or in a water/alcohol solvent.  
     
     
         7 . The method of  claim 6  wherein said solvent further includes at least one acidulent and at least one water dispersible polymer.  
     
     
         8 . The method of  claim 7  wherein the acidulent is citric acid and the water dispersible polymer is polyvinyl pyrrolidone (PVP).