Anti-fungal composition

Abstract

An anti-fungal product for delivering at least two different anti-fungals that is comprised of three dosage forms with different release profiles with each anti-fungal being present in at least one of the dosage forms.

What is claimed is:  
     
         1 . An anti-fungal product comprising: 
 at least three dosage forms, each dosage form comprising an anti-fungal and a pharmaceutically acceptable carrier, one of said dosage forms including at least a first anti-fungal and a second of said dosage forms including at least a second anti-fungal that is different than the first anti-fungal.    
     
     
         2 . The product of  claim 1  wherein each of the dosage forms has a different release profile.  
     
     
         3 . The product of  claim 1  wherein the first dosage form is an immediate release dosage form.  
     
     
         4 . The product of  claim 3  wherein the second and third dosage forms are delayed release dosage forms.  
     
     
         5 . The product of  claim 4  wherein anti-fungal released from the second dosage form reaches a C max  in serum after anti-fungal released from the first dosage form reaches C max  in serum.  
     
     
         6 . The product of  claim 5  wherein anti-fungal released from the third dosage form reaches C max  in serum after anti-fungal released from the second dosage form reaches C max  in serum.  
     
     
         7 . The product of  claim 6  wherein total anti-fungal released from the product reaches C max  in serum within twelve hours of administration.  
     
     
         8 . The product of  claim 7  wherein the product is a once a day product.  
     
     
         9 . The product of  claim 1  wherein each of the three dosage forms includes at least the first and second anti-fungal.  
     
     
         10 . The product of  claim 1  wherein the first dosage form includes the first anti-fungal, the second dosage form includes the first and second anti-fungal and the fourth dosage form includes the second anti-fungal.  
     
     
         11 . An anti-fungal product comprising: a first, second, third and fourth dosage form, said first dosage form comprising a first anti-fungal and a pharmaceutically acceptable carrier; said second dosage form comprising said first anti-fungal and a pharmaceutically acceptable carrier; said third dosage form comprising a second anti-fungal different from the first anti-fungal and a pharmaceutically acceptable carrier; said fourth dosage form comprising said second anti-fungal and a pharmaceutically acceptable carrier, said second and third dosage forms having a release profile whereby the maximum serum concentration of the first anti-fungal and the second anti-fungal released from the second and third dosage forms is reached at a time later than the maximum serum concentration of the first anti-fungal released from the first dosage form, and wherein the maximum serum concentration of the second anti-fungal released from the fourth dosage form reaches a maximum serum concentration at a time after the maximum serum concentration for the anti-fungal released from each of the first, second and third dosage forms is reached.  
     
     
         12 . The composition of  claim 1  wherein the first anti-fungal released from the second dosage form, and the second anti-fungal released from the third dosage form reach a maximum serum concentration at about the same time.  
     
     
         13 . A process for treating a fungus infection in a host comprising: 
 administering to the host the anti-fungal product of  claim 1 .    
     
     
         14 . A process for treating a fungus infection in a host comprising: 
 administering to the host the anti-fungal product of  claim 2 .    
     
     
         15 . A process for treating a fungus infection in a host comprising: 
 administering to the host the anti-fungal product of  claim 3 .    
     
     
         16 . A process for treating a fungus infection in a host comprising: 
 administering to the host the anti-fungal product of  claim 4 .    
     
     
         17 . A process for treating a fungus infection in a host comprising: 
 administering to the host the anti-fungal product of  claim 5 .    
     
     
         18 . A process for treating a fungus infection in a host comprising: 
 administering to the host the anti-fungal product of  claim 6 .    
     
     
         19 . A process for treating a fungus infection in a host comprising: 
 administering to the host the anti-fungal product of  claim 7 .    
     
     
         20 . A process for treating a fungus infection in a host comprising: 
 administering to the host the anti-fungal product of claim  8 .