Protecting against canine oral papillomavirus (COPV)

Abstract

Recombinantly produced LI major capsid proteins which mimic conformational naturalizing epitopes on human and animal papilloma virions including canine and equine papilloma virions are provided. These recombinant proteins are useful as vaccines for conferring protection against papillomavirus infection. Antibodies to the recombinant protein are also provided. Such antibodies are useful in the diagnosis and treatment of viral infection.

What is claimed is:  
     
         14 . A vaccine for conferring protection against human papillomavirus (HPV) infection in a human susceptible to human papillomavirus infection which comprises (i) a prophylatically effective amount of an extract comprising a formalin-treated human papillomavirus L1 protein and (ii) a pharmaceutically acceptable carrier.  
     
     
         16 . The vaccine of claim  14  wherein said human papillomavirus is selected from the group consisting of HPV 1, HPV 2, HPV 3, HPV 4, HPV 6, HPV 7, HPV 10,HPV 11, HPV 12, HPV 16 and HPV 18.  
     
     
         17 . A method of protecting a human against human PV infection comprising administering a prophylatically effective amount of a vaccine according to claim  14 .  
     
     
         20 . The method of claim  17 , wherein said administered vaccine comprises a formalin-inactivated human papillomavirus selected from the group consisting of HPV1, HPV2, HPV3, HPV4, HPV6, HPV7, HPV10, HPV11, HPV12, HPV16 and HPV18.