Wound coverings for removal of interfering factors from wound fluid

Abstract

The invention relates to novel wound coverings with which interfering factors of the wound healing process can be removed from the wound fluid of chronic wounds in a controlled manner and the normal healing process is promoted.

1 . Use of substances which interact with interfering factors present in wound exudate which impede the wound healing process for the production of wounds coverings, the interfering factors being chosen from the group consisting of suspended cells and cell fragments and dissolved constituents, such as antigens, free radicals, ions, proteins, peptides, lipids and free fatty acids, the interaction comprising bonding, complexing or chelating of the interfering factor or a chemical reaction with the interfering factor, and the substances being covalently bonded to a carrier material.  
     
     
         2 . Use according to  claim 1 , characterized in that the substance is chosen from the group consisting of antibodies, chelators, enzyme inhibitors, enzymes, peptides and other proteins.  
     
     
         3 . Use according to claims  1  and  2 , characterized in that the carrier material is a polymeric carrier material of natural or synthetic origin.  
     
     
         4 . Use according to  claim 3 , characterized in that the polymeric carrier material is chosen from the group consisting of cellulose and derivatives thereof, alginates, hyaluronic acid, chitin, chitosans, polysaccharides, polyamides, polyesters, polyolefins, polyacrylates, polyvinyl alcohols, polyurethanes and silicones, including mixtures and copolymers thereof.  
     
     
         5 . Use according to  claims 1  to  4 , characterized in that the wound covering is chosen from the group consisting of dressings, dressing gauze, bandages, compresses, cotton-wool, patches, foils, films, hydrocolloid dressings, gels and the like.  
     
     
         6 . Use according to  claims 1  to  5 , characterized in that the interfering factors are cons and the substance which interacts with the interfering factors is a chelator.  
     
     
         7 . Use according to  claim 6 , characterized in that the chelator is chosen from the group consisting of deferrioxamine, diethylenetriaminepentaacetic acid, N,N′-bis-(o-hydroxybenzyl)-ethylenediamine-N,N′-diacetic acid, 1,2-dimethyl-3-hydroxy-pyrid-4-one and 1,2-dimethyl-3-hydroxyl-3-hydroxypyridin-4-one.  
     
     
         8 . Use according to  claim 7 , characterized in that the interfering factors are iron(III) ions and the substance which interacts with the interfering factors is deferrioxamine.  
     
     
         9 . Use according to  claims 1  to  5 , characterized in that the interfering factors are reactive oxygen radicals and the substance which interacts with the interfering factors is an agent which traps free radicals.  
     
     
         10 . Use according to  claim 9 , characterized in that the agent which traps free radicals is chosen from the group consisting of superoxide dismutase, catalase, glutathione peroxidase, myeloperoxidase and enzyme mimics or another combination thereof.  
     
     
         11 . Use according to  claims 1  to  5 , characterized in that the interfering factor is a protease and the substance which interacts with the interfering factor is a protease inhibitor.  
     
     
         12 . Use according to  claim 11 , characterized in that the protease inhibitor is chosen from the group consisting or antipain, leupeptin, cystain, pepstatin, diisopropyl fluorophosphate, 4-(aminoethyl)-phenylsulphonyl fluoride, phenylmethanesulphonyl fluoride, naturally occurring proteinogenic protease inhibitors from the class of tissue inhibitors of matrix metalloproteinases, aprotinin, alpha-2-antiplasmin, alpha-2-macroglobulin, alpha-1-antichymotrypsin, soya bean trypsin inhibitor and alpha-1-protease inhibitor.  
     
     
         13 . Wound covering, characterized in that substances which interact with interfering factors present in wound exudate which impede wound healing are covalently bonded to a carrier material, the interfering factors being chosen from the group consisting of suspended cells and cell fragments and dissolved constituents, such as antigens, bacteria, free radicals, ions, proteins, peptides, lipids and free fatty acids, and the interaction comprising bonding, complexing or chelating of the interfering factor or a chemical reaction with the interfering factor.  
     
     
         14 . Wound covering accord-ng to  claim 13 , characterized in that the substance is chosen from the group consisting of antibodies, chelators, enzyme inhibitors, enzymes, enzyme mimics peptides and other proteins.  
     
     
         15 . Wound covering according to claims  13  and  14 , characterized in that the carrier material is a polymeric carrier material of natural or synthetic origin.  
     
     
         16 . Wound covering according to  claim 15 , characterized in that the polymeric carrier material is chosen from the group consisting of cellulose and derivatives thereof, alginates, hyaluronic acid, chitin, chitosans, polysaccharides, polyamides, polyesters, polyolefins, polyacrylates, polyvinyl alcohols, polyurethanes and silicones, including mixtures and copolymers thereof.  
     
     
         17 . Wound covering according to  claims 13  to  16 , characterized in that the wound covering is chosen from the group consisting of dressings, dressing gauze, bandages, compresses, cotton-wool, patches, foils, films, hydrocolloid dressings, gels and the like.  
     
     
         18 . Wound covering according to  claims 13  to  17 , characterized in that the interfering factors are ions and the substance which interacts with the interfering factors is a chelator.  
     
     
         19 . Wound covering according to  claim 18 , characterized in that the chelator is chosen from the group consisting of deferrioxamine, diethylenetriaminepentaacetic acid, N,N′-bis-(o-hydroxybenzyl)-ethylenediamine-N,N′-diacetic acid, 1,2-dimethyl-3-hydroxy-pyrid-4-one and 1,2-dimethyl-3-hydroxyl-3-hydroxypyridin-4-one.  
     
     
         20 . Wound covering according to  claim 19 , characterized in that the interfering factors are iron(III) ions and the substance which interacts with the interfering factors is deferrioxamine.  
     
     
         21 . Wound covering according to  claims 13  to  17 , characterized in that the interfering factors are reactive oxygen radicals and the substance which interacts with the interfering factors is an agent which traps free radicals.  
     
     
         22 . Wound covering according to  claim 21 , characterized in that the agent which traps free radicals is chosen from the group consisting of superoxide dismutase, catalase, glutathione peroxidase, myeloperoxidase and enzyme mimics or a combination thereof.  
     
     
         23 . Wound covering according to  claims 13  to  17 , characterized in that the interfering factor is a protease and the substance which interacts with the interfering factor is a protease inhibitor.  
     
     
         24 . Wound covering according to  claim 23 , characterized in that the protease inhibitor is chosen from the group consisting of antipain, leupeptin, cystain, pepstatin, diisopropyl fluorophosphate, 4-(aminoethyl)phenylsulphonyl fluoride, phenylmethane-sulphonyl fluoride, naturally occurring proteinogenic protease inhibitors from the class of tissue inhibitors of matrix metalloproteinases, aprotinin, alpha-2-antiplasmin, alpha-2-macroglobulin, alpha-1-antichymotrypsin, soya bean trypsin inhibitor and alpha-1-protease inhibitor.  
     
     
         25 . Wound covering according to  claims 13  to  24 , characterized in that it additionally comprises substances which promote wound healing.  
     
     
         26 . Wound covering according to  claim 25 , characterized in that the substances which promote wound healing are growth factors.  
     
     
         27 . Wound covering according to  claims 13  to  26 , characterized in that it absorbs moisture.  
     
     
         28 . Process for the production of a wound covering according to  claims 13  to  27 , characterized in that the substance which interacts with the interfering factor is covalently bonded to the carrier material by chemical reaction.