US2002192283A1PendingUtilityA1

Odor-masking coating for a pharmaceutical preparation

43
Priority: Dec 30, 1999Filed: May 14, 2002Published: Dec 19, 2002
Est. expiryDec 30, 2019(expired)· nominal 20-yr term from priority
Inventors:I-Lan SuePou-Hsiung Wang
A61P 25/22A61P 25/20A61K 9/2886A61K 36/84
43
PatentIndex Score
0
Cited by
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References
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Claims

Abstract

A coating for masking or reducing the detectable presence of certain characteristic odor or odors, taste or tastes of pharmaceutical preparations, particularly Valerian extracts, is described. The coating comprises from one to three coating compartments, in any combination or as a single-layer amalgam. The first coating compartment comprises a hydroxyalkyl cellulose and an anti-tackiness agent. The second coating compartment may comprise a sugar and at least one anti-tackiness agent. The third coating compartment may comprise a methacrylate copolymer, a hydroxyalkyl cellulose and an anti-tackiness agent.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A tablet comprising: 
 a pharmaceutically-inert coating, wherein the coating comprises a polymer film-forming agent; and    a tablet core, wherein the tablet core comprises a pharmaceutically effective amount of an extract of the root of Valerian, wherein the tablet core is coated by the pharmaceutically-inert coating.    
     
     
         2 . The tablet of  claim 1 , wherein the polymer film-forming agent is selected from the group consisting of a hydroxyalkyl cellulose wherein the alkyl group has between 1 and 10 carbon atoms, and a methacrylate copolymer.  
     
     
         3 . The tablet of  claim 2 , wherein said hydroxyalkyl cellulose is selected from the group consisting of hydroxyethyl cellulose and hydroxypropyl cellulose.  
     
     
         4 . The tablet of  claim 2 , wherein said methacrylate copolymer is selected from the group consisting of methacrylic acid copolymers, aminoalkylmethacrylate copolymers, and ammoniomethacrylate copolymers.  
     
     
         5 . The tablet of  claim 1 , wherein the pharmaceutically-inert coating further comprises a plasticizer.  
     
     
         6 . The tablet of  claim 5 , wherein said plasticizer is selected from the group consisting of propylene glycol, glycerin, trimethylolpropane, polyethylene glycols, dibutyl sebacate, acetylated monoglycerides, diethylphthalate, triacetin, glyceryl triacetate, acetyltriethyl citrate and triethyl citrate.  
     
     
         7 . The tablet of  claim 1 , wherein the pharmaceutically-inert coating further comprises an anti-tackiness agent.  
     
     
         8 . The tablet of  claim 7 , wherein said anti-tackiness agent is selected from the group consisting of talc, silicon dioxide, silica hydrogel, microcrystalline cellulose, alkali stearates, and starch.  
     
     
         9 . The tablet of  claim 1 , wherein the pharmaceutically-inert coating further comprises hydroxypropyl methylcellulose.  
     
     
         10 . The tablet of  claim 1 , wherein the pharmaceutically-inert coating comprises a water soluble polymer or compound.  
     
     
         11 . The tablet of  claim 10 , wherein said water soluble polymer is selected from the group consisting of hydroxypropyl cellulose, hydroxypropyl methylcellulose, acacia, sodium carboxymethylcellulose, dextrin, alginic acid, ethylcellulose resin, gelatin, guar gum, liquid glucose, methylcellulose, pregelatinized starch, sodium alginate, starch, zein, polyvinylpyrrolindone, vinylpyrrolidone-vinyl acetate copolymer, vinyl acetate-crotonic acid copolymer and ethyl acrylate-methacrylic acid copolymer.  
     
     
         12 . The tablet of  claim 1 , wherein the pharmaceutically-inert coating further comprises an odor-masking agent.  
     
     
         13 . The tablet of  claim 12 , wherein the odor-masking agent has an odor that is more pleasant than the odor of the extract of the root of Valerian.  
     
     
         14 . The tablet of  claim 1 , wherein the tablet core further comprises an odor-masking agent.  
     
     
         15 . The tablet of  claim 14 , wherein the odor-masking agent has an odor that is more pleasant than the odor of the extract of the root of Valerian.  
     
     
         16 . The tablet of  claim 1 , wherein the coating further comprises a colorant.  
     
     
         17 . The tablet of  claim 1 , wherein the coating further comprises a scent.  
     
     
         18 . The tablet of  claim 1 , wherein the coating further comprises a flavoring agent.  
     
     
         19 . The tablet of  claim 1 , wherein the tablet core further comprises a disintegrant.  
     
     
         20 . The tablet of  claim 1 , wherein the tablet core further comprises a filler.  
     
     
         21 . The tablet of  claim 20 , wherein the filler is spray dried lactose monohydrate.  
     
     
         22 . A tablet comprising: 
 a pharmaceutically-inert coating, wherein the coating comprises a first polymer film-forming agent, a second polymer film-forming agent, and a plasticizer; and    a tablet core, wherein the table core comprises a pharmaceutically effective amount of an extract of the root of Valerian, wherein the tablet core is coated by the pharmaceutically-inert coating.    
     
     
         23 . The tablet of  claim 22 , wherein the tablet core further comprises a disintegrant.  
     
     
         24 . The tablet of  claim 22 , wherein the tablet core further comprises a filler.  
     
     
         25 . The tablet of  claim 24 , wherein the filler is spray dried lactose monohydrate.  
     
     
         26 . The tablet of  claim 22 , wherein the first polymer film-forming agent is selected the group consisting of a hydroxyalkyl cellulose wherein the alkyl group has between 1 and 10 carbon atoms, and a methacrylate copolymer.  
     
     
         27 . The tablet of  claim 26 , wherein said hydroxyalkyl cellulose is selected from the group consisting of hydroxyethyl cellulose and hydroxypropyl cellulose.  
     
     
         28 . The tablet of  claim 26 , wherein said methacrylate copolymer is selected from the group consisting of methacrylic acid copolymers, aminoalkylmethacrylate copolymers, and ammoniomethacrylate copolymers.  
     
     
         29 . The tablet of  claim 22 , wherein the second polymer film-forming agent comprises a methacrylate copolymer, a hydroxyalkyl cellulose and an anti-tackiness agent.  
     
     
         30 . The tablet of  claim 22 , wherein the pharmaceutically-inert coating further comprises a plasticizer.  
     
     
         31 . The tablet of  claim 30 , wherein said plasticizer is selected from the group consisting of propylene glycol, glycerin, trimethylolpropane, polyethylene glycols, dibutyl sebacate, acetylated monoglycerides, diethylphthalate, triacetin, glyceryl triacetate, acetyltriethyl citrate and triethyl citrate.  
     
     
         32 . The tablet of  claim 22 , wherein the pharmaceutically-inert coating further comprises an anti-tackiness agent.  
     
     
         33 . The tablet of  claim 32 , wherein said anti-tackiness agent is selected from the group consisting of talc, silicon dioxide, silica hydrogel, microcrystalline cellulose, alkali stearates, and starch.  
     
     
         34 . The tablet of  claim 22 , wherein the pharmaceutically-inert coating further comprises hydroxypropyl methylcellulose.  
     
     
         35 . The tablet of  claim 22 , wherein the pharmaceutically-inert coating comprises a water soluble polymer or compound.  
     
     
         36 . The tablet of  claim 35 , wherein said water soluble polymer is selected from the group consisting of hydroxypropyl cellulose, hydroxypropyl methylcellulose, acacia, sodium carboxymethylcellulose, dextrin, alginic acid, ethylcellulose resin, gelatin, guar gum, liquid glucose, methylcellulose, pregelatinized starch, sodium alginate, starch, zein, polyvinylpyrrolindone, vinylpyrrolidone-vinyl acetate copolymer, vinyl acetate-crotonic acid copolymer and ethyl acrylate-methacrylic acid copolymer.  
     
     
         37 . The tablet of  claim 22 , wherein the pharmaceutically-inert coating further comprises an odor-masking agent.  
     
     
         38 . The tablet of  claim 37 , wherein the odor-masking agent has an odor that is more pleasant than the odor of the extract of the root of Valerian.  
     
     
         39 . The tablet of  claim 22 , wherein the tablet core further comprises an odor-masking agent.  
     
     
         40 . The tablet of  claim 39 , wherein the odor-masking agent has an odor that is more pleasant than the odor of the extract of the root of Valerian.  
     
     
         41 . The tablet of  claim 22 , wherein the coating further comprises a colorant.  
     
     
         42 . The tablet of  claim 22 , wherein the coating further comprises a scent.  
     
     
         43 . The tablet of  claim 22 , wherein the coating further comprises a flavoring agent.

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