US2002188170A1PendingUtilityA1

Prevention of myocardial infarction induced ventricular expansion and remodeling

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Priority: Apr 27, 2001Filed: Apr 25, 2002Published: Dec 12, 2002
Est. expiryApr 27, 2021(expired)· nominal 20-yr term from priority
Inventors:William SantamoreJeanne M. Lesniak
A61B 17/0644A61B 2017/00862Y10S623/904A61F 2002/249A61B 2017/0443A61B 17/3468A61B 2017/0649A61B 2017/00243A61B 2017/0412A61K 9/0024A61B 2017/0422A61F 2/2451A61K 38/1841A61B 2018/00392A61B 17/064A61B 2017/0427A61P 9/10A61B 2017/048A61B 2017/0404A61F 2/2493A61B 17/068A61B 2017/0647A61B 2017/044A61K 9/14A61B 2017/00247A61B 2017/0464A61B 2017/0437A61M 25/09A61P 9/00A61B 17/00234A61K 49/0013A61K 47/02A61B 17/00491A61K 49/04A61B 2017/0641A61B 17/0401A61K 47/42A61B 18/1815A61B 17/0469
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Claims

Abstract

A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying a target region of the myocardium and applying material directly and substantially only to at least a portion of the myocardial tissue of the target region. The material applied results in a physically modification the mechanical properties, including stiffness, of said tissue. Various devices and modes of practicing the method are disclosed for stiffening, restraining and constraining myocardial tissue for the treatment of conditions including myocardial infarction or mitral valve regurgitation.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A method for direct localized therapeutic treatment of myocardial tissue in heart having a pathological condition comprising the steps of: 
 a. identifying a target region of the myocardium;    b. applying material directly and substantially only to at least a portion of the myocardial tissue of the target region substantially identified in step (a) to physically modify the mechanical properties of said tissue.    
     
     
         2 . The method of  claim 1  wherein the modified mechanical properties include an increase in systolic performance.  
     
     
         3 . The method of  claim 2  wherein the modified mechanical properties include substantially no decrease in global diastolic performance.  
     
     
         4 . The method of  claim 1 , wherein the material applied is passive.  
     
     
         5 . The method of  claim 1 , wherein said target region includes a myocardial infarct.  
     
     
         6 . The method of  claim 1 , wherein said target region at least in part underlies the papillary muscles associated with a cardiac valve.  
     
     
         7 . The method of  claim 6 , wherein said cardiac valve is the mitral valve.  
     
     
         8 . The method of  claim 1 , wherein said material applied to the myocardial tissue is a device.  
     
     
         9 . The method of  claim 1 , wherein said material applied to the myocardial tissue comprises a polymer.  
     
     
         10 . The method of  claim 1 , wherein said material applied to the myocardial tissue comprises microspheres.  
     
     
         11 . The method of  claim 1 , wherein said material applied to the myocardial tissue comprises a bioactive agent.  
     
     
         12 . The method of  claim 1 , wherein said applying step includes employing a catheter.  
     
     
         13 . The method of  claim 12  wherein said catheter is employed percutaneously.  
     
     
         14 . The method of  claim 1 , wherein said applying step is preceded by performing a mini-thoracotomy  
     
     
         15 . The method of  claim 1 , wherein said applying step includes applying material intramyocardially.

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