Medicine, drink, food and feed having an action of strengthening bone

Abstract

The present invention is to provide a novel medicine, drink, food or feed having an action of strengthening bone. More specifically, the present invention is to provide a medicine, drink, food or feed combined with collagen, fraction containing collagen or degradation product thereof. Fraction containing collagen was prepared by mincing skin corium layer into pieces, defatting it and lyophylization or by pulverizing bone, decalcifying it and lyophylization. Oral administration of these can stimulate proliferation of osteoblast, inhibit bone resorption and strengthen bone. They can be useful for improvement of osteoporosis, bone fracture, bone pain, etc.

We claim,  
     
         1 . A medicine, drink, food or feed having an action of strengthening bone combined with collagen, fraction containing collagen and/or degradation product thereof.  
     
     
         2 . The medicine, drink, food or feed according to  claim 1 , wherein said fraction containing collagen is skin protein fraction or bone protein fraction.  
     
     
         3 . The medicine, drink, food or feed according to  claim 2 , wherein said skin protein fraction is a lyophylization product of pulverized and fefatted skin corium layer.  
     
     
         4 . The medicine, drink, food or feed according to  claim 2 , wherein said bone protein fraction is a lyophylization product of pulverized and decalcified bone.  
     
     
         5 . The medicine, drink, food or feed according to  claim 1 , wherein said fraction containing collagen is treated skin protein fraction or bone protein fraction by soaking it in acid or alkaline solution.  
     
     
         6 . The medicine, drink, food or feed according to  claim 1 , wherein said degradation product of fraction containing collagen is degradation product with molecular weight of 2-150 kDa obtained by hydrolysis of skin protein fraction or bone protein fraction with proteolytic enzyme.  
     
     
         7 . The medicine, drink, food or feed according to  claim 1 , wherein said degradation product of fraction containing collagen is degradation product with molecular weight of 2-150 kDa obtained by hydrolysis of acid- or alkaline-treated skin protein fraction or bone protein fraction with a proteolytic enzyme.  
     
     
         8 . A medicine, drink, food or feed containing collagen, fraction containing collagen and/or degradation product thereof combined with calcium and/or vitamins.  
     
     
         9 . The medicine, drink, food or feed according to  claim 8 , wherein 0.5-5.0 weight parts of collagen, fraction containing collagen or degradation product thereof is combined with 1 weight part of calcium.