Rehydration composition

Abstract

The invention relates to a fluid that can be used for preventing or treating hypohydration and the secondary consequences thereof. The fluid comprises one or more carbohydrates and minerals and is further characterized by a low osmolarity. The invention further relates to the use of such a fluid for medical, dietetic and other applications.

1 . A fluid for preventing or treating hypohydration, comprising a methyl amine and/or a flavonolignan, said fluid further comprising one or more digestible carbohydrates and one or more minerals, wherein said fluid has an essentially hypotonic osmolarity.  
     
     
         2 . A fluid according to  claim 1 , having an osmolarity of 300 mOsm/l or less.  
     
     
         3 . A fluid according to  claim 1 , having a dry mass content of 9 wt. % or less.  
     
     
         4 . A fluid according to  claim 1 , wherein the digestible carbohydrate concentration is between 10 and 80 g/l.  
     
     
         5 . A fluid according to  claim 1 , wherein one or more carbohydrates are chosen from the group of oligosaccharides and polysaccharides.  
     
     
         6 . A fluid according to  claim 1 , wherein one or more carbohydrates have an average chain length in the range of 3-50 monosaccharide units.  
     
     
         7 . A fluid according to  claim 1 , wherein at least 50 wt. % of the carbohydrate content is in the form of oligosaccharides and/or polysaccharides.  
     
     
         8 . A fluid according to  claim 1 , wherein one or more carbohydrates comprise glucose and at least one of the monosaccharides chosen from the group of fructose, galactose, mannose, ribose and inositol.  
     
     
         9 . A fluid according to  claim 8 , wherein the amount of fructose and mannose together is 0.05-0.6 mole per mole glucose.  
     
     
         10 . A fluid according to  claim 1 , wherein one or more carbohydrates comprise at least 0.5 g/l ribose, at least 0.5 g/l inositol and/or at least 0.5 g/l galactose.  
     
     
         11 . A fluid according to  claim 1 , wherein said methyl amine is betaine.  
     
     
         12 . A fluid according to  claim 1 , wherein the methylamine concentration is 0.1-0.20 g/l.  
     
     
         13 . A fluid according to  claim 1 , wherein said flavonolignan is silibin.  
     
     
         14 . A fluid according to  claim 1 , wherein said flavonolignan is concentration is 0.1-8 g/l.  
     
     
         15 . A fluid according to  claim 1 , comprising silymarin as a source for silibin.  
     
     
         16 . A fluid according to  claim 15 , wherein the silymarin concentration is between 0.2 and 10 g/l.  
     
     
         17 . A fluid according to  claim 1 , wherein the mineral concentration is between 0.1 and 30 g/l.  
     
     
         18 . A fluid according to  claim 1 , wherein one or more minerals are chosen from the group formed by sodium, potassium, chloride, phosphate, magnesium, zinc, calcium, iron and copper.  
     
     
         19 . A fluid according to  claim 18 , wherein the magnesium concentration is 100 mg/l or more.  
     
     
         20 . A fluid according to  claim 18 , wherein the zinc concentration is 10 mg/l or more.  
     
     
         21 . A fluid according to  claim 18 , wherein the calcium concentration is 300 mg/l or more.  
     
     
         22 . A fluid according to  claim 18 , wherein the iron concentration is 5 mg/l or more.  
     
     
         23 . A fluid according to  claim 1 , comprising glycerol, lipoic acid, a vitamin, citrate, phosphate, malate, taurine, caffeine or a combination thereof.  
     
     
         24 . A fluid according to  claim 23 , comprising tocopherol.  
     
     
         25 . A fluid according to  claim 23 , wherein glycerol is present in a concentration of 0.1-20 g/l.  
     
     
         26 . A fluid according to  claim 23 , wherein lipoic acid is present in a concentration of at least 20 mg/l.  
     
     
         27 . A fluid according to  claim 23 , wherein taurine is present in a concentration of 0.2-2 g/l.  
     
     
         28 . A fluid according to  claim 23 , wherein caffeine is present in a concentration of 0.1-1 g/l.  
     
     
         29 . A fluid according to  claim 1  comprising methionine.  
     
     
         30 . A fluid according to  claim 1 , having a pH in the range of 2.5-6.8.  
     
     
         31 . A fluid according to  claim 1 , having a nitrogen content of less than 3 g/l.  
     
     
         32 . A fluid according to  claim 1  in the form of a water solution, a fruit juice, a whey dairy drink, a beverage, a fluid for tube or enteric administration.  
     
     
         33 . A method for treating or preventing hypohydration, comprising the administration of a fluid according to  claim 1 .  
     
     
         34 . A method according to  claim 33 , wherein the fluid is administered orally or by tube or enteral administration.  
     
     
         35 . A method according to  claim 33 , comprising the administration of said fluid to a subject suffering from a gut disorder, cystic fibrosis, a cardiovascular disease or a physiologically or symptomatically related disorder.  
     
     
         36 . A method according to  claim 33 , wherein the fluid is administered before, during or after the subject is subjected to surgery.  
     
     
         37 . A method according to  claim 33  for the prevention or treatment of deyhydration of a subject who is exposed to a high temperature and/or physical exercise, wherein the fluid is administered to the subject before, during and/or after being exposed to a high temperature and/or physical exercise.  
     
     
         38 . A method according to  claim 33 , wherein the subject is an elderly person.  
     
     
         39 . A method according to  claim 33 , for medical use.  
     
     
         40 . A method for manufacturing a fluid according to  claim 1  for preventing or treating hypohydration.  
     
     
         41 . Concentrate for preparation of a fluid according to  claim 1 .  
     
     
         42 . Concentrate according to  claim 41  in the form of a pre-mix, a powder, an agglomerate, a fluid, a syrup, a gel, a tablet or a capsule.  
     
     
         43 . A method for manufacturing a concentrate according to  claim 41 , for preventing or treating hypohydration.  
     
     
         44 . Use of a methylamine and/or flavonolignan in a hypotonic fluid to provide improved prevention against hypohydration.  
     
     
         45 . Use of methylamine and/or flavonolignan in a hypotonic fluid to provide improved recovery from hypohydration.