Nuclear matrix proteins

Abstract

Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.

1 . A method for detecting a cell proliferative disorder in a subject comprising contacting a cellular component with a reagent which binds to PC-1 (prostate cancer-1) protein.  
     
     
         2 . The method of  claim 1 , wherein the cell proliferative disorder is in urogenital tissue.  
     
     
         3 . The method of  claim 2 , wherein the urogenital tissue is the prostate.  
     
     
         4 . The method of  claim 1 , wherein the cellular component is the nucleic acid.  
     
     
         5 . The method of  claim 4 , wherein the nucleic acid is DNA.  
     
     
         6 . The method of  claim 4 , wherein the nucleic acid is RNA.  
     
     
         7 . The method of  claim 1 , wherein the reagent is a probe.  
     
     
         8 . The method of  claim 7 , wherein the reagent is nucleic acid.  
     
     
         9 . The method of  claim 7 , wherein the probe is detectably labeled.  
     
     
         10 . The method of  claim 9 , wherein the label is selected from the group consisting of a radioisotope, a bioluminescent compound, a chemiluminescent compound, a fluorescent compound, a metal chelate, or an enzyme.