US2002165363A1PendingUtilityA1

Cachexia remedy

27
Priority: May 15, 1997Filed: May 13, 1998Published: Nov 7, 2002
Est. expiryMay 15, 2017(expired)· nominal 20-yr term from priority
Inventors:Koh SatoToshiaki TsunenariKimie Ishii
C07K 2319/00A61P 35/00C07K 14/635A61K 38/00A61K 2039/505C07K 2317/24C07K 16/26A61K 38/29
27
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Claims

Abstract

The invention relates to a therapeutic agent for cachexia comprising, as an active ingredient, a substance capab;le of inhibiting the binding between a parathyroid hormone related protein (PTHrP) and a receptor thereof.

Claims

exact text as granted — not AI-modified
1 . A therapeutic agent for cachexia comprising, as an active ingredient, a substance capable of inhibiting the binding between parathyroid hormone related protein (PTHrP) and a receptor thereof.  
     
     
         2 . The therapeutic agent for cachexia of  claim 1 , wherein the substance is an antagonist against the PTHrP.  
     
     
         3 . The therapeutic agent for cachexia of  claim 1 , wherein the substance is an anti-PTHrP antibody.  
     
     
         4 . The therapeutic agent for cachexia of  claim 1 , wherein the substance is a fragment of an anti-PTHrP antibody and/or a modified fragment thereof.  
     
     
         5 . The therapeutic agent for cachexia of  claim 3  or  4 , wherein the antibody is a humanized or chimeric antibody.  
     
     
         6 . The therapeutic agent for cachexia of  claim 5 , wherein the humanized antibody is humanized #23-57-137-1 antibody.  
     
     
         7 . The therapeutic agent for cachexia of  claim 3  or  4 , wherein the antibody is of monoclonal type.  
     
     
         8 . The therapeutic agent for cachexia of any of  claims 1  to  7 , wherein the cachexia is one induced by cancer.

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