Method for preventing and treating inflammatory somatic pain and chronic pain

Abstract

The invention relates to the use of trimebutine [2-dimethylamino-2-phenylbutyl-3,4,5-trimethoxy-benzoate hydrogen maleate] or its corresponding stereoisomers for the preparation of a medicament to prevent and/or treat inflammatory somatic pain as well as chronic pain.

1 . Use of Trimebutine [2-dimethylamino-2-phenylbutyl-3,4,5-trimethoxy-benzoate hydrogen maleate] or its corresponding stereoisomers for the preparation of a medicament to prevent and/or treat inflammatory somatic pain.  
     
     
         2 . Use of Trimebutine [2-dimethylamino-2-phenylbutyl-3,4,5-trimethoxy-benzoate hydrogen maleate] or its corresponding stereoisomers for the preparation of a medicament to prevent and/or treat chronic pain.  
     
     
         3 . Use according to  claim 1  or  2  wherein the trimebutine is administered orally.  
     
     
         4 . Use according to  claim 1  or  2  wherein the trimebutine is administered by injection and preferably by intravenous injection.  
     
     
         5 . Use according to  claim 3  or  4  wherein the trimebutine is administered at dosage between 50 to 900 mg/day and preferably between 300 to 600 mg/day  
     
     
         6 . Use according to one of the preceding claims to prevent and/or treat hyperalgesia  
     
     
         7 . Use according to one of the preceding claims to prevent and/or treat pain related to central hypersensitivity conditions.  
     
     
         8 . Use according to one of the preceding claims to prevent and/or treat neurological pain.  
     
     
         9 . Use according to one of the preceding claims to prevent and/or treat arthritis.  
     
     
         10 . Use according to one of the preceding claims to prevent and/or treat osteo-traumatic pain.  
     
     
         11 . Use according to one of the preceding claims to prevent and/or treat back pain.  
     
     
         12 . Use according to one of the preceding claims to prevent and/or treat cancer pain.  
     
     
         13 . Use according to one of the preceding claims to prevent and/or treat HIV related pain.  
     
     
         14 . Use according to one of the preceding claims to prevent and/or treat neuralgias including post-herpetic neuralgia.  
     
     
         15 . Use according to one of the preceding claims to prevent and/or treat vascular pain.  
     
     
         16 . Method for preventing or treating somatic pain comprising administering trimebutine to a patient in need thereof.  
     
     
         17 . Method for preventing or treating chronic pain comprising administering to a patient in need thereof.