US2002164690A1PendingUtilityA1

Receptor based antagonists and methods of making and using

47
Priority: Sep 25, 1998Filed: Aug 23, 2001Published: Nov 7, 2002
Est. expirySep 25, 2018(expired)· nominal 20-yr term from priority
Inventors:Neil Stahl
A61P 35/00C07K 14/715A61P 19/10C07K 2319/02
47
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Claims

Abstract

The present invention provides a fusion polypeptide that forms a multimer that is capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion polypeptide.

Claims

exact text as granted — not AI-modified
We claim,  
     
         1 . An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS.  38 A- 38 H encoding a fusion polypeptide having the amino acid sequence set forth in FIGS.  38 A- 38 H, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.  
     
     
         2 . An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS.  39 A- 39 G encoding a fusion polypeptide having the amino acid sequence set forth in FIGS.  39 A- 39 G, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.  
     
     
         3 . An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS.  40 A- 40 I encoding a fusion polypeptide having the amino acid sequence set forth in FIGS.  40 A- 40 I, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.  
     
     
         4 . An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS.  41 A- 41 H encoding a fusion polypeptide having the amino acid sequence set forth in FIGS.  41 A- 41 H, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.  
     
     
         5 . An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS.  42 A- 42 I encoding a fusion polypeptide having the amino acid sequence set forth in FIGS.  42 A- 42 I, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.  
     
     
         6 . An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS.  43 A- 43 G encoding a fusion polypeptide having the amino acid sequence set forth in FIGS.  43 A- 43 G, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.  
     
     
         7 . An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS.  44 A- 44 I encoding a fusion polypeptide having the amino acid sequence set forth in FIGS.  44 A- 44 J, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.  
     
     
         8 . An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS.  45 A- 45 I encoding a fusion polypeptide having the amino acid sequence set forth in FIGS.  45 A- 45 I, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.  
     
     
         9 . An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS.  46 A- 461  encoding a fusion polypeptide having the amino acid sequence set forth in FIGS.  46 A- 46 I, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.  
     
     
         10 . An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS.  47 A- 47 J encoding a fusion polypeptide having the amino acid sequence set forth in FIGS.  47 A- 47 J, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.  
     
     
         11 . A fusion polypeptide having the amino acid sequence set forth in FIGS.  38 A- 38 H encoded by the isolated nucleic acid molecule of  claim 1 .  
     
     
         12 . A fusion polypeptide having the amino acid sequence set forth in FIGS.  39 A- 39 G encoded by the isolated nucleic acid molecule of  claim 2 .  
     
     
         13 . A fusion polypeptide having the amino acid sequence set forth in FIGS.  40 A- 40 I encoded by the isolated nucleic acid molecule of  claim 3 .  
     
     
         14 . A fusion polypeptide having the amino acid sequence set forth in FIGS.  41 A- 41 H encoded by the isolated nucleic acid molecule of  claim 4 .  
     
     
         15 . A fusion polypeptide having the amino acid sequence set forth in FIGS.  42 A- 42 I encoded by the isolated nucleic acid molecule of  claim 5 .  
     
     
         16 . A fusion polypeptide having the amino acid sequence set forth in FIGS.  43 A- 43 G encoded by the isolated nucleic acid molecule of  claim 6 .  
     
     
         17 . A fusion polypeptide having the amino acid sequence set forth in FIGS.  44 A- 44 I encoded by the isolated nucleic acid molecule of  claim 7 .  
     
     
         18 . A fusion polypeptide having the amino acid sequence set forth in FIGS.  45 A- 45 I encoded by the isolated nucleic acid molecule of  claim 8 .  
     
     
         19 . A fusion polypeptide having the amino acid sequence set forth in FIGS.  46 A- 46 I encoded by the isolated nucleic acid molecule of  claim 9 .  
     
     
         20 . A fusion polypeptide having the amino acid sequence set forth in FIGS.  47 A- 47 J encoded by the isolated nucleic acid molecule of claim  10 .

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