US2002156146A1PendingUtilityA1

Molecular weight reduction of polymer using irradiation treatment

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Assignee: GENZYME CORPPriority: Jul 19, 2000Filed: Apr 1, 2002Published: Oct 24, 2002
Est. expiryJul 19, 2020(expired)· nominal 20-yr term from priority
Inventors:Robert J. MillerAviva Shiedlin
C08B 37/0072C08B 11/20
43
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Claims

Abstract

Polymer compositions having reduced molecular weight prepared by a method which comprises subjecting a solid phase polymer to a dose of gamma irradiation sufficient to permit the desired molecular weight reduction to occur.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A reduced-molecular weight composition prepared by the process consisting of the steps of: 
 providing an initial polymer in the solid phase having an initial molecular weight, and    subjecting the polymer to irradiation in a dosage amount sufficient to reduce the molecular weight of the polymer to a final molecular weight that is lower than the initial molecular weigh    to thereby obtain a substantially pure polymer product having the reduced molecular weight.    
     
     
         2 . The composition of  claim 1  wherein the polymer is in powder form.  
     
     
         3 . The composition of  claim 1  wherein the polymer is a polysaccharide polymer.  
     
     
         4 . The composition of  claim 3  wherein the polymer is hyaluronic acid.  
     
     
         5 . The composition of  claim 3  wherein the polymer is carboxymethyl cellulose.  
     
     
         6 . The composition of  claim 1  wherein the molecular structure of the polymer is intact after reducing the molecular weight of the polymer.  
     
     
         7 . The composition of  claim 1  wherein the irradiation used is gamma irradiation.  
     
     
         8 . The composition of  claim 7  wherein the dosage level of the gamma irradiation is from about 1 kGy to about 120 kGy.  
     
     
         9 . The composition of  claim 1  wherein the polymer product has a polydispersity index substantially similar to the initial polymer.  
     
     
         10 . The composition of  claim 1  wherein the polydispersity index of polymer product is less than 10% higher than the polydispersity index of the initial polymer.  
     
     
         11 . The composition of  claim 1  wherein the polymer product has a final molecular weight of 340 KDa or less.  
     
     
         12 . The composition of  claim 1  wherein the polymer product has a final molecular weight of 290 KDa or less.  
     
     
         13 . The composition of  claim 1  wherein the polymer product has a final molecular weight of 260 KDa or less.  
     
     
         14 . The composition of  claim 1  wherein the polymer product has a final molecular weight of 210 KDa or less.  
     
     
         15 . The composition of  claim 1  wherein the polymer product has a final molecular weight of 180 KDa or less.  
     
     
         16 . The composition of  claim 1  wherein the polymer product has a final molecular weight of 110 KDa or less.  
     
     
         17 . The composition of  claim 1  wherein the polymer product has a final molecular weight of 90 KDa or less.  
     
     
         18 . The composition of  claim 1  wherein the polymer has an initial molecular weight of about 1100 KDa or more.

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