FT-0554 substance and its production

Abstract

The present invention is to obtain novel FT-0554 substance which is useful for treatment of helminthiasis. The present invention comprising the steps of culturing the microorganism belonging to fungi having producing activity of FT-0554 substance represented by the following formula [I] subjected to accumulation of FT-0554 substance in the cultured medium, and isolating FT-0554 substance from the said cultured mass. The medicament useful for treatment of parasitic infection, specifically helminthiasis can be obtained.

1 . A process for producing FT-0554 substance of formula [1] 
       
         
           
           
               
               
           
         
       
       comprising culturing a microrganism belonging to fungi having activity for producing FT-0554 substance in a medium, accumulating FT-0554 substance in the cultured medium and isolating FT-0554 substance from said culture.  
     
     
         2 . The process according to  claim 1 , wherein said microorganism is  Aspergillus niger  FT-0554.  
     
     
         3 . The process according to  claim 1 , wherein said microorganism is  Aspergillus niger  FT-0554 FERM BP-6443.  
     
     
         4 . The process according to  claim 1 , wherein said microorganism is cultured at a ph of 3-10 and a temperature of 12-45° C.  
     
     
         5 . The process according to  claim 1 , wherein said microorganism is cultured at a ph of 5-7 and a temperature of 16-36° C.  
     
     
         6 . The process according to  claim 1 , wherein said medium is a liquid.  
     
     
         7 . The process according to  claim 1 , wherein said medium contains seawater.  
     
     
         8 . The process according to  claim 1 , wherein said microorganism is cultured at a ph of 3-10, a temperature of 12-45° C. and in a medium comprising 50-100% seawater.  
     
     
         9 . A microorganism belonging to fungi and having the ability to produce FT-0554.  
     
     
         10 . The microorganism according to  claim 9 , wherein said microorganism is  Aspergillus niger  FT-0554.  
     
     
         11 . The microorganism according to  claim 9 , wherein said microorganism is  Aspergillus niger  FT-0554 FERM BP-6443.  
     
     
         12 . A biologically pure culture of  Aspergillus niger  FT-0554 FERM BP-6443.