Material for removing beta-2 microglobulin from blood

Abstract

A material for removing beta-2 microglobulin from blood by passing the blood through the material which are hydrophilic and biocompatible a size and a structure selected so as to remove beta-2 microglobulin from the blood, wherein said material is a porous beaded polydivinylbenzene or polystyrene-co-polydivinylbenzene polymer with a surface of [the] beads and of pores modified so as to prevent adsorption of large proteins and platelets and to minimize activation of blood complement system without affecting noticeably accessibility of an inner absorption space of the beads for beta-2 microglobulin and middle-sized toxicant molecules, in which polymer surface exposed vinyl groups are chemically modified so as to form different surface exposed functional groups which are hydrophilic and biocompatible.

1 . A material for removing beta-2 microglobulin from blood by passing the blood through the material which are hydrophilic and biocompatible a size and a structure selected so as to remove beta-2 microglobulin from the blood, wherein said material is a porous beaded polydivinylbenzene or polystyrene-co-polydivinylbenzene polymer with a surface of beads and of pores modified so as to prevent adsorption of large proteins and platelets and to minimize activation of blood complement system without affecting noticeably accessibility of an inner absorption space of the beads for beta-2 microglobulin and middle-sized toxicant molecules, in which polymer surface exposed vinyl groups are chemically modified so as to form different surface exposed functional groups which are hydrophilic and biocompatible.  
     
     
         2 . A material for removing beta-2 microglobulin from blood as defined in  claim 1 , wherein the beads contain more than 50% of divinylenzene.  
     
     
         3 . A material for removing beta-2 microglobulin from blood as defined in  claim 1 , wherein the beads contain more than 60% of divinylenzene.  
     
     
         4 . A material for removing beta-2 microglobulin from blood as defined in  claim 1 , wherein the beads contain more than 75% of divinylenzene.  
     
     
         5 . A material for removing beta-2 microglobulin from blood as defined in  claim 1 , wherein the beads contain 55% of divinylenzene.  
     
     
         6 . A material for removing beta-2 microglobulin from blood as defined in  claim 1 , wherein the beads contain 65% of divinylenzene.  
     
     
         7 . A material for removing beta-2 microglobulin from blood as defined in  claim 1 , wherein the beads contain 80% of divinylenzene.