Method of treating sepsis and ARDS using chemokine alpha-2

Abstract

The invention relates to the method of preventing and treating sepsis and ARDS using chemokine or biologically active fragment thereof, alone or in conjunction with an anti-infective agent.

What is claimed is:  
     
         1 . A method of treating sepsis and ARDS comprising administering to an animal in need thereof an effective amount of chemokine selected from the group consisting of: 
 (a) Macrophage Inflammatory Protein-Gamma;    (b) Macrophage Inflammatory Protein-3 and-4;    (c) Macrophage Migration Inhibitory Factor-3;    (d) Human Chemokine Beta-9;    (e) Human Chemokine Polypeptides;    (f) Human Chemokine Beta-11 and Human Chemokine Alpha-1;    (g) Human Chemokine Beta-13;    (h) Human Chemokine Beta-12;    (i) Chemokine Alpha-2;    (j) chemokine Alpha-3;    (k) Novel Chemokine for Mobilizing Stem Cells;    (l) Short Form Chemokine Beta-8; or biologically active fragments thereof.    
     
     
         2 . A method according to  claim 1  wherein said effective amount is from about 1 to about 100 mg/kg/dose.  
     
     
         3 . The method according to  claim 1  wherein chemokine is administered orally.  
     
     
         4 . The method according to  claim 1  wherein chemokine is administered subcutaneously.  
     
     
         5 . A method of treating sepsis and ARDS comprising administering to an animal in need thereof an effective amount of chemokine or biologically active fragments thereof in conjunction with an effective amount of an anti-infective agent.  
     
     
         6 . A method according to  claim 5  wherein the anti-infective agent is selected from the group consisting of gentamicin, augmentin or ceftazidime.  
     
     
         7 . A method for the prevention of sepsis and ARDS comprising administering to an animal in need thereof an effective amount of chemokine or biologically active fragment thereof.  
     
     
         8 . A method according to  claim 7  wherein the effective amount is from about 1 to about 100 mg/kg/dose.  
     
     
         9 . The method according to  claim 7  wherein cheomkine or biologically active fragment thereof is administered 1 to 2 days prior to surgery.  
     
     
         10 . A method for the prevention of sepsis and ARDS comprising administering to an animal in need thereof an effective amount of chemokine or biologically active fragment thereof, in conjunction with an effective amount of an anti-infective agent.  
     
     
         11 . A method according to  claim 10  wherein the anti-infective agent is selected from the group consisting of gentamicin, augmentin or ceftazidime.  
     
     
         12 . A method for the treatment of sepsis and ARDS comprising administering to an animal in need thereof an effective amount of chemokine or biologically active fragment thereof.  
     
     
         13 . A method according to  claim 12  wherein the effective amount is from about 1 to about 100 mg/kg/dose.  
     
     
         14 . The method according to  claim 12  wherein chemokine or biologically active fragment thereof is administered 2 hours to 24 hours after surgery.  
     
     
         15 . A method for the treatment of sepsis and ARDS comprising administering to an animal in need the an effective amount of chemokine or biologically active fragment thereof, in conjunction with an effective amount of an anti-infective agent.  
     
     
         16 . A method according to  claim 15  wherein the anti-infective agent is selected from the group consisting of gentamicin, augmentin or ceftazidime.